Oxfendazole

Generic Name
Oxfendazole
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C15H13N3O3S
CAS Number
53716-50-0
Unique Ingredient Identifier
OMP2H17F9E
Background

Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.

Associated Conditions
-
Associated Therapies
-
Clinical Trials
Related News

One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole in Chronic Fascioliasis

Phase 2
Not yet recruiting
Conditions
Fascioliasis
Interventions
Drug: Oxfendazole
Drug: Triclabendazole
First Posted Date
2024-04-16
Last Posted Date
2024-08-16
Lead Sponsor
Universidad Peruana Cayetano Heredia
Target Recruit Count
336
Registration Number
NCT06367361

PK, Safety and Tolerability of Single and Multiple Doses of Oxfendazole Tablets

Phase 1
Completed
Conditions
Filariasis
Interventions
Drug: Oxfendazole
Drug: Placebo
First Posted Date
2021-06-09
Last Posted Date
2022-12-20
Lead Sponsor
Swiss Tropical & Public Health Institute
Target Recruit Count
30
Registration Number
NCT04920292
Locations
🇹🇿

Ifakara Health Institute, Bagamoyo, Tanzania

A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults

Phase 2
Not yet recruiting
Conditions
Trichuriasis
Interventions
Drug: Oxfendazole
Drug: Albendazole
First Posted Date
2021-01-19
Last Posted Date
2023-09-18
Lead Sponsor
Asociacion Benefica Prisma
Target Recruit Count
249
Registration Number
NCT04713787
Locations
🇵🇪

Policlinico Asociacion Benefica PRISMA-Laboratorio Satelite IQTLAB, Iquitos, Maynas, Peru

Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults

Phase 2
Not yet recruiting
Conditions
Trichuris Infection
Interventions
Drug: Oxfendazole
Drug: Albendazole
First Posted Date
2018-02-19
Last Posted Date
2023-11-08
Lead Sponsor
Oxfendazole Development Group
Target Recruit Count
250
Registration Number
NCT03435718

Multiple Ascending Dose Study of Oxfendazole in Healthy Adult Volunteers

Phase 1
Completed
Conditions
Helminthic Infection
Interventions
Drug: Oxfendazole
First Posted Date
2017-01-30
Last Posted Date
2019-12-17
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
36
Registration Number
NCT03035760
Locations
🇺🇸

University of Iowa - Vaccine Research and Education Unit, Iowa City, Iowa, United States

Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults

Phase 2
Withdrawn
Conditions
Helminthiasis
Interventions
Drug: oxfendazole
Drug: albendazole
First Posted Date
2015-12-22
Last Posted Date
2019-08-15
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Registration Number
NCT02636803

Phase I Trial Evaluating the Safety and Pharmacokinetics of Oxfendazole

Phase 1
Completed
Conditions
Neurocysticercosis
Interventions
Drug: Oxfendazole
Other: Placebo
First Posted Date
2014-09-09
Last Posted Date
2020-11-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
70
Registration Number
NCT02234570
Locations
🇺🇸

University of Iowa - Vaccine Research and Education Unit, Iowa City, Iowa, United States

Single Ascending Dose Safety Study of Oxfendazole

Phase 1
Withdrawn
Conditions
Tenia Solium Infection
Interventions
Drug: placebo
Drug: oxfendazole
First Posted Date
2012-04-25
Last Posted Date
2016-08-30
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Registration Number
NCT01584362
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