Tacrolimus

Generic Name
Tacrolimus
Brand Names
Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic, Tacforius
Drug Type
Small Molecule
Chemical Formula
C44H69NO12
CAS Number
104987-11-3
Unique Ingredient Identifier
Y5L2157C4J
Background

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condi...

Indication

Immediate-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants. Extended-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric ...

Associated Conditions
Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Kidney Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Oral Lichen Planus, Psoriasis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Atopic Dermatitis, Vitiligo, Moderate Atopic dermatitis
Associated Therapies
-
Clinical Trials
Related News

Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation

First Posted Date
2018-07-27
Last Posted Date
2021-06-30
Lead Sponsor
Fred Hutchinson Cancer Center
Registration Number
NCT03602898
Locations
🇺🇸

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States

Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)

First Posted Date
2018-06-08
Last Posted Date
2019-04-03
Lead Sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Target Recruit Count
108
Registration Number
NCT03549663
Locations
🇨🇳

Shanghai Xinhua Hospital affliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, Shanghai, China

Tacrolimus Treatment for Refractory PRCA

Phase 4
Conditions
Pure Red Cell Aplasia
Interventions
Drug: tacrolimus
First Posted Date
2018-05-30
Last Posted Date
2018-05-30
Lead Sponsor
Peking Union Medical College Hospital
Target Recruit Count
30
Registration Number
NCT03540472
Locations
🇨🇳

Peking Union Medical College Hospital, Beijing, Beijing, China

Human Lysozyme Goat Milk in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant

First Posted Date
2018-05-21
Last Posted Date
2018-12-07
Lead Sponsor
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Registration Number
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Locations
🇺🇸

City of Hope Medical Center, Duarte, California, United States

Optimizing Immunosuppression Drug Dosing Via Phenotypic Precision Medicine

First Posted Date
2018-05-17
Last Posted Date
2021-12-10
Lead Sponsor
University of Florida
Target Recruit Count
62
Registration Number
NCT03527238
Locations
🇺🇸

UCLA, Los Angeles, California, United States

🇸🇬

National University of Singapore, Singapore, Singapore

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UF Health at the University of Florida, Gainesville, Florida, United States

Envarsus on the Effect of Total Tacrolimus Dose/Trough Level Ratio on Renal Function (eGFR) in Kidney Transplantation

First Posted Date
2018-04-30
Last Posted Date
2024-07-17
Lead Sponsor
Columbia University
Target Recruit Count
50
Registration Number
NCT03511560
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Sirolimus-based Immunosuppression Treatment Regimen for Liver Transplantation

First Posted Date
2018-04-18
Last Posted Date
2018-04-18
Lead Sponsor
Southern Medical University, China
Target Recruit Count
130
Registration Number
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Locations
🇨🇳

First Affiliated Hospital, Sun Yat-Sen University, Guanzhou, Guangdong, China

🇨🇳

Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China

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Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

First Posted Date
2018-03-29
Last Posted Date
2024-07-23
Lead Sponsor
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Target Recruit Count
21
Registration Number
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Locations
🇺🇸

Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, New Hampshire, United States

Total Marrow and Lymphoid Irradiation Before Donor Transplant and Cyclophosphamide in Treating Patients With Acute Myeloid Leukemia

First Posted Date
2018-03-16
Last Posted Date
2024-02-16
Lead Sponsor
City of Hope Medical Center
Target Recruit Count
18
Registration Number
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Locations
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City of Hope Medical Center, Duarte, California, United States

A Study to Compare the Finger Prick Whole Blood MITRA Assay Method With the Established Venepuncture Whole Blood Method for Quantitative Determination of Tacrolimus Blood Concentrations in Transplant Patients

First Posted Date
2018-03-15
Last Posted Date
2018-10-15
Lead Sponsor
Astellas Pharma Europe Ltd.
Target Recruit Count
80
Registration Number
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Locations
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Site FR33002, Toulouse, France

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Site FR33001, Villejuif, France

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Site UK44001, London, United Kingdom

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