MedPath

Aloe vera leaf

Generic Name
Aloe vera leaf
Brand Names
Alcortin A, Aloquin
Drug Type
Biotech
CAS Number
8001-97-6
Unique Ingredient Identifier
ZY81Z83H0X

Overview

Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or Aloe barbadensis miller, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated . The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties . Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose . Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation .

Background

Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or Aloe barbadensis miller, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated . The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties . Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose . Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation .

Indication

Indicated for use as a topical agent to soothe sensitive skin and to relieve symptoms of various skin conditions, including contact or atopic dermatitis, eczema, dermatitis and acne urticata, first- and second-degree burns, radiation dermatitis, and sunburn.

Associated Conditions

  • Acne
  • Atopic Dermatitis
  • Contact dermatitis and other eczema
  • Dermatosis
  • Folliculitis
  • Intertrigo
  • Lichen simplex chronicus
  • Moniliasis
  • Nummular Dermatitis
  • Pruritus Ani
  • Pyoderma
  • Stasis dermatitis
  • Disseminated Neurodermatitis
  • Genital pruritus
  • Localized Neurodermatitis

FDA Approved Products

Alcortin A
Manufacturer:Primus Pharmaceuticals
Route:TOPICAL
Strength:10 mg in 1 g
Approved: 2009/10/30
NDC:68040-705
IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES
Manufacturer:Syntenza Pharmaceuticals LLC
Route:TOPICAL
Strength:10 mg in 1 g
Approved: 2020/05/06
NDC:72056-020
Aloquin
Manufacturer:Primus Pharmaceuticals
Route:TOPICAL
Strength:10 mg in 1 g
Approved: 2009/10/07
NDC:68040-706
IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES
Manufacturer:Gabar Health Sciences Corp.
Route:TOPICAL
Strength:10 mg in 1 g
Approved: 2023/03/04
NDC:82429-119
API STRESS COAT
Manufacturer:MARS FISHCARE NORTH AMERICA, INC.
Route:TOPICAL
Strength:0.05 g in 100 mL
Approved: 2025/03/21
NDC:17163-085

Singapore Approved Products

SANKAIJO TABLET
Manufacturer:SATO PHARMACEUTICAL CO., LTD. HSINCHU FACTORY
Form:TABLET, FILM COATED
Strength:12.5 mg
Online:Yes
Approved: 1989/06/24
Approval:SIN03486P

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