Cefiderocol
- Generic Name
- Cefiderocol
- Brand Names
- Fetroja, Fetcroja
- Drug Type
- Small Molecule
- Chemical Formula
- C30H34ClN7O10S2
- CAS Number
- 1225208-94-5
- Unique Ingredient Identifier
- SZ34OMG6E8
- Background
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics. Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as it has proven to ...
- Indication
Cefiderocol is indicated for the treatment of complicated urinary tract infections with or without pyelonephritis.
- Associated Conditions
- Complicated Urinary Tract Infection, Nosocomial Pneumonia, Pyelonephritis, Ventilator Associated Bacterial Pneumonia (VABP)
- Associated Therapies
- -
A DDI Study to Investigate PK and Safety of Cefiderocol in Combination With Xeruborbactam in Healthy Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Qpex Biopharma, Inc.
- Target Recruit Count
- 40
- Registration Number
- NCT06547554
- Locations
- 🇺🇸
Minneapolis Clinic, Minneapolis, Minnesota, United States
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
- Conditions
- Interventions
- First Posted Date
- 2023-10-17
- Last Posted Date
- 2024-06-05
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 40
- Registration Number
- NCT06086626
- Locations
- 🇨🇳
Chang Gung Memorial Hospital, Linkou Department of Pediatrics, Taoyuan City, Taiwan
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States
🇿🇦Tygerberg Hospital, Cape Town, Western Cape, South Africa
Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii
- Conditions
- Interventions
- First Posted Date
- 2023-06-28
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 734
- Registration Number
- NCT05922124
Use of Cefiderocol in the Management of Gram-Negative Infections
- First Posted Date
- 2023-03-29
- Last Posted Date
- 2023-06-26
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 314
- Registration Number
- NCT05789199
- Locations
- 🇪🇸
Complejo Hospitalario Universitario de Albacete, Albacete, Spain
🇪🇸Hospital Universitario Torrecardenas, Almeria, Almeria, Spain
🇪🇸Hospital General Universitario Gregorio Marañón, Madrid, Spain
A Study to Assess the Effect of Cefiderocol on the Pharmacokinetics (PK) of Midazolam in Healthy Participants
- First Posted Date
- 2022-05-27
- Last Posted Date
- 2023-12-14
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 14
- Registration Number
- NCT05395104
- Locations
- 🇺🇸
Worldwide Clinical Trials, San Antonio, Texas, United States
Cefiderocol Plasma Concentrations in Patients Receiving Renal Replacement Therapy
- First Posted Date
- 2022-05-13
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- Hartford Hospital
- Target Recruit Count
- 14
- Registration Number
- NCT05373615
- Locations
- 🇺🇸
Hartford Hospital, Hartford, Connecticut, United States
Cefiderocol Pharmacokinetics in Adult Patients With Cystic Fibrosis
- First Posted Date
- 2022-04-06
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Hartford Hospital
- Target Recruit Count
- 10
- Registration Number
- NCT05314764
- Locations
- 🇺🇸
Hartford Hospital, Hartford, Connecticut, United States
🇺🇸IU Health University Hospital, Indianapolis, Indiana, United States
🇺🇸UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania, United States
Cefiderocol PK in Patients on ECMO
- First Posted Date
- 2021-08-09
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Joseph L. Kuti, PharmD
- Target Recruit Count
- 5
- Registration Number
- NCT04995835
- Locations
- 🇺🇸
Hartford Hospital, Hartford, Connecticut, United States
🇺🇸Columbia University/New York Presbyterian Hospital, New York, New York, United States
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants
- First Posted Date
- 2020-04-06
- Last Posted Date
- 2024-01-24
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 54
- Registration Number
- NCT04335539
- Locations
- 🇱🇻
Bernu Kliniska Universitates Slimnica Childrens Hospital - Tornakalna, Riga, Latvia
🇪🇪Tartu Ulikooli Kliinikum - Anestesioloogia ja Intensiivravi Kliinik, Tartu, Estonia
🇬🇪JSC "Medical Corporation Evex" " M. Iashvili Batumi Maternal and Child Central Hospital", Batumi, Georgia
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Pediatric Participants
- First Posted Date
- 2020-01-02
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 85
- Registration Number
- NCT04215991
- Locations
- 🇺🇸
University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, United States
🇬🇪JSC "EVEX Medical Corporation"- M Lashvili Childrens Central Hospital, Tbilisi, Georgia
🇬🇪Ltd Unimedi Kakheti Childrens New Clinic, Tbilisi, Georgia
Drug Development Updates
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