Clarithromycin

Generic Name
Clarithromycin
Brand Names
Biaxin, Biaxin Bid, Omeclamox, Prevpac, Voquezna 14 Day Triplepak 20;500;500
Drug Type
Small Molecule
Chemical Formula
C38H69NO13
CAS Number
81103-11-9
Unique Ingredient Identifier
H1250JIK0A
Background

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

Indication

An alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for Mycobacterium avium complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection).

Clarithromycin is indicated in combination with vonoprazan and amoxicillin as co-packaged triple therapy to treat Helicobacter pylori (H. pylori) infection in adults.

Associated Conditions
Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Acute maxillary sinusitis, Bacterial Infections, Bartonellosis, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Helicobacter Pylori Infection, Infective Endocarditis (IE), Lyme Disease, Mycobacterial Infections, Otitis Media (OM), Pertussis, Streptococcal Pharyngitis, Tonsillitis streptococcal, Uncomplicated skin and subcutaneous tissue bacterial infections
Associated Therapies
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The PK and PD Interaction Between YH4808, Amoxicillin and Clarithromycin in Healthy Subjects

First Posted Date
2013-08-13
Last Posted Date
2013-12-03
Lead Sponsor
Yuhan Corporation
Target Recruit Count
95
Registration Number
NCT01921647
Locations
🇰🇷

Yonsei University Severance Hospital, Seoul, Korea, Republic of

15-day Sequential Therapy for Helicobacter Pylori Infection in Korea

First Posted Date
2013-06-26
Last Posted Date
2013-08-13
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
287
Registration Number
NCT01887249
Locations
🇰🇷

Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, Korea, Republic of

Pharmacokinetic Study of Clarithromycin in Very Low Birth Weight (VLBW)

First Posted Date
2013-05-13
Last Posted Date
2014-11-19
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
6
Registration Number
NCT01851954
Locations
🇰🇷

Seoul National University Children's Hospital, Seoul, Korea, Republic of

The Effect of Gemfibrozil, Ketoconazole and Clarithromycin on the Amount of LY2409021 in the Bloodstream

First Posted Date
2013-04-19
Last Posted Date
2019-03-08
Lead Sponsor
Eli Lilly and Company
Target Recruit Count
30
Registration Number
NCT01836198
Locations
🇺🇸

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Evansville, Indiana, United States

Autologous Stem Cell Transplant With Pomalidomide (CC-4047®) Maintenance Versus Continuous Clarithromycin/ Pomalidomide / Dexamethasone Salvage Therapy in Relapsed or Refractory Multiple Myeloma

First Posted Date
2012-12-10
Last Posted Date
2024-07-03
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
23
Registration Number
NCT01745588
Locations
🇺🇸

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

🇺🇸

North Shore LIJ, New Hyde Park, New York, United States

🇺🇸

Memorial Sloan Kettering Cancer Center @ Suffolk, Commack, New York, United States

and more 6 locations

Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori

First Posted Date
2012-08-17
Last Posted Date
2013-06-04
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
180
Registration Number
NCT01667575
Locations
🇨🇳

Renji Hospital, Shanghai, Shanghai, China

Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients

First Posted Date
2012-05-08
Last Posted Date
2015-08-17
Lead Sponsor
Zagazig University
Target Recruit Count
70
Registration Number
NCT01593592
Locations
🇪🇬

Zagazig University Hospitals, Zagazig, Sharkia, Egypt

Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) [Car-BiRD] Therapy for Subjects With Multiple Myeloma

First Posted Date
2012-03-21
Last Posted Date
2024-03-26
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
74
Registration Number
NCT01559935
Locations
🇺🇸

Weill Cornell Medical College, New York, New York, United States

Efficacy of TAK-438, Amoxicillin and Clarithromycin in the First Line Eradication of H. Pylori

First Posted Date
2012-01-06
Last Posted Date
2013-11-05
Lead Sponsor
Takeda
Target Recruit Count
650
Registration Number
NCT01505127

Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane

First Posted Date
2012-01-04
Last Posted Date
2022-04-20
Lead Sponsor
Samsung Medical Center
Target Recruit Count
151
Registration Number
NCT01503606
Locations
🇰🇷

Samsung Medical center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

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