Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including ...
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-06-04
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 77
- Registration Number
- NCT00042874
- Locations
- 🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States
High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-11-06
- Lead Sponsor
- Robert Roessle Klinik
- Registration Number
- NCT00004150
- Locations
- 🇧🇪
Universitair Ziekenhuis Antwerpen, Edegem, Belgium
🇫🇷CHR de Besancon - Hopital Jean Minjoz, Besancon, France
🇫🇷Centre Hospitalier de Bourgoin - Jallieu, Bourgoin-Jallieu, France
Combination Chemotherapy in Treating Patients With Colorectal Cancer
- Conditions
- Locations
- 🇫🇷
Hopital Saint-Louis, Paris, France
🇫🇷Centre de Lutte Contre le Cancer Georges-Francois Leclerc, Dijon, France
🇫🇷Centre Hospital Regional Universitaire de Limoges, Limoges, France
Vinorelbine Plus Fluorouracil in Treating Women With Metastatic Breast Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2012-07-02
- Target Recruit Count
- 80
- Registration Number
- NCT00003730
- Locations
- 🇧🇪
VZW Monica Campus Eeuwfeestkliniek, Antwerpen, Belgium
🇬🇷University Hospital of Heraklion, Iraklion (Heraklion), Crete, Greece
🇮🇹Istituto per la Ricerca e Cura del Cancro, Candiolo (Turin), Italy
Fluorouracil With or Without Cisplatin in Treating Patients With Advanced or Metastatic Cancer of the Pancreas
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2012-07-02
- Target Recruit Count
- 200
- Registration Number
- NCT00003029
- Locations
- 🇫🇷
Centre Hospitalier de la Cote Basque, Bayonne, France
🇫🇷Hopital Perpetuel Secours, Levallois-Perret, France
🇧🇪Les Cliniques Saint-Joseph ASBL, Liege, Belgium
Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2012-06-28
- Lead Sponsor
- Wellstat Therapeutics
- Target Recruit Count
- 250
- Registration Number
- NCT00024427
- Locations
- 🇺🇸
University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, United States
🇺🇸Cancer Center at Greater Baltimore Medical Center, Baltimore, Maryland, United States
🇺🇸Fox Chase - Temple Cancer Center, Philadelphia, Pennsylvania, United States
Whole Body Hyperthermia Combined With Chemotherapy in Treating Patients With Metastatic Breast, Ovarian, Endometrial, or Cervical Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2009-04-30
- Target Recruit Count
- 34
- Registration Number
- NCT00003135
- Locations
- 🇺🇸
University of Texas Health Science Center at Houston, Houston, Texas, United States
Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer
- Conditions
- Locations
- 🇫🇷
Hopital Claude Gallien, Quincy Sous Senart, France
🇫🇷Hopital Laennec, Paris, France
🇫🇷Polyclinique Jeanne d'Arc - service de Radiotherapie Oncologie, Gien, France
Combination Chemotherapy in Treating Women With Resected Breast Cancer
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2009-02-09
- Lead Sponsor
- Institute of Cancer Research, United Kingdom
- Registration Number
- NCT00033683
- Locations
- 🇬🇧
St. Georges Hospital Medical School, London, England, United Kingdom
🇬🇧Huddersfield Royal Infirmary, Huddersfield, West Yorks, England, United Kingdom
🇬🇧Leicester Royal Infirmary, Leicester, England, United Kingdom
Combination Chemotherapy Combined With Radiation Therapy in Treating Patients Who Have Stage II or Stage III Cancer of the Esophagus
- Conditions
- Locations
- 🇫🇷
Centre Jean Bernard, Le Mans, France
🇫🇷Clinique Saint - Jean, Cagne-sur-Mer, France
🇫🇷Hopital Andre Mignot, Le Chesnay, France
Drug Development Updates
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