Overview
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Associated Conditions
- Actinic Keratosis (AK)
- Breast Cancer
- Colon Cancer
- Gastric Cancer
- Pancreatic Cancer
- Rectal Cancer
- Superficial Basal Cell Carcinoma
- Verruca (Warts)
- Hyperkeratotic actinic keratosis
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2013/06/28 | Phase 2 | Withdrawn | |||
2013/06/24 | Phase 2 | Completed | Arbeitsgemeinschaft medikamentoese Tumortherapie | ||
2013/06/20 | Phase 2 | Completed | |||
2013/06/19 | Phase 1 | UNKNOWN | Association Tunisienne de lutte Contre le Cancer | ||
2013/06/06 | Phase 2 | UNKNOWN | |||
2013/05/24 | Phase 2 | Completed | |||
2013/05/20 | Early Phase 1 | Completed | |||
2013/05/17 | Phase 2 | Completed | |||
2013/05/08 | Phase 4 | UNKNOWN | Shandong University | ||
2013/05/06 | Phase 1 | Completed |
FDA Drug Approvals
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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Health Canada Drug Approvals
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CIMA AEMPS Drug Approvals
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Philippines FDA Drug Approvals
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Saudi SFDA Drug Approvals
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Malaysia NPRA Drug Approvals
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UK EMC Drug Information
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