Fluorouracil

Generic Name: Fluorouracil

Brand Names: Actikerall, Carac, Efudex, Fluoroplex, Tolak

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃FN_₂O_₂

CAS Number: 51-21-8

Unique Ingredient Identifier: U3P01618RT

Background: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.

Indication: For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.

Associated Conditions: Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis

Associated Therapies: -

Clinical Trials

Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx

Phase 3

Completed

Conditions: Head and Neck Cancer

First Posted Date: 2004-06-09

Last Posted Date: 2014-01-24

Lead Sponsor: Radiation Therapy Oncology Group

Registration Number: NCT00002496

Locations: 🇺🇸
CCOP - Carle Cancer Center, Urbana, Illinois, United States
🇺🇸
CCOP - Kalamazoo, Kalamazoo, Michigan, United States
🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

and more 15 locations

Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer

Phase 3

Completed

Conditions: Head and Neck Cancer

First Posted Date: 2004-06-09

Last Posted Date: 2013-08-02

Lead Sponsor: Cancer Research UK

Registration Number: NCT00002476

Locations: 🇬🇧
Derriford Hospital, Plymouth, England, United Kingdom
🇬🇧
Southend General Hospital, Westcliff-On-Sea, England, United Kingdom
🇬🇧
Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom

and more 4 locations

Eniluracil, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Colorectal Cancer

Phase 1

Completed

Conditions: Colorectal Cancer

First Posted Date: 2004-06-08

Last Posted Date: 2011-03-28

Lead Sponsor: NYU Langone Health

Registration Number: NCT00005050

Locations: 🇺🇸
Kaplan Cancer Center, New York, New York, United States

Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver

Phase 3

Conditions: Colorectal Cancer
Metastatic Cancer

First Posted Date: 2004-05-21

Last Posted Date: 2013-12-19

Lead Sponsor: Medical Research Council

Target Recruit Count: 312

Registration Number: NCT00002692

Locations: 🇬🇧
University Birmingham, Birmingham, England, United Kingdom

Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer

Phase 3

Conditions: Breast Cancer

First Posted Date: 2004-05-20

Last Posted Date: 2013-12-18

Lead Sponsor: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

Target Recruit Count: 1000

Registration Number: NCT00005581

Locations: 🇮🇹
Ospedale S. Paolo, Savona, Italy
🇮🇹
Ospedale Oncologico A. Businco, Cagliari, Italy
🇮🇹
I.R.C.C.S. Policlinico San Matteo, Pavia, Italy

and more 21 locations

Chemotherapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas or Bile Duct

Phase 2

Conditions: Extrahepatic Bile Duct Cancer
Pancreatic Cancer

First Posted Date: 2004-05-20

Last Posted Date: 2009-02-09

Lead Sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group

Registration Number: NCT00010088

Locations: 🇫🇷
Polyclinique De Courlancy, Reims, France
🇫🇷
Centre Saint-Yves, Vannes, France
🇫🇷
Institut Bergonie, Bordeaux, France

and more 47 locations

Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus

Phase 3

Completed

Conditions: Esophageal Cancer

Interventions: Drug: cisplatin
Drug: fluorouracil
Procedure: surgical procedure
Radiation: radiation therapy

First Posted Date: 2004-05-19

Last Posted Date: 2016-07-04

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 56

Registration Number: NCT00003118

Locations: 🇺🇸
University of Illinois at Chicago Health Sciences Center, Chicago, Illinois, United States
🇺🇸
University of Chicago Cancer Research Center, Chicago, Illinois, United States
🇺🇸
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States

and more 35 locations