Fluorouracil
- Generic Name
- Fluorouracil
- Brand Names
- Actikerall, Carac, Efudex, Fluoroplex, Tolak
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3FN2O2
- CAS Number
- 51-21-8
- Unique Ingredient Identifier
- U3P01618RT
- Background
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
- Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
- Associated Conditions
- Actinic Keratosis (AK), Breast Cancer, Colon Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer, Superficial Basal Cell Carcinoma, Verruca (Warts), Hyperkeratotic actinic keratosis
- Associated Therapies
- -
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Pancreatic Cancer That Cannot Be Removed by Surgery
- Conditions
- First Posted Date
- 2004-02-12
- Last Posted Date
- 2013-04-05
- Lead Sponsor
- Barbara Ann Karmanos Cancer Institute
- Target Recruit Count
- 30
- Registration Number
- NCT00004003
- Locations
- 🇺🇸
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Combination Chemotherapy Plus Bevacizumab in Treating Patients With Advanced Colorectal Cancer
- Conditions
- First Posted Date
- 2004-02-12
- Last Posted Date
- 2013-06-24
- Lead Sponsor
- Eastern Cooperative Oncology Group
- Registration Number
- NCT00006786
- Locations
- 🇺🇸
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States
🇺🇸Veterans Affairs Medical Center - Cleveland, Cleveland, Ohio, United States
🇺🇸Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer
- Conditions
- First Posted Date
- 2004-02-12
- Last Posted Date
- 2013-06-19
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT00006038
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum
- Conditions
- Interventions
- First Posted Date
- 2004-02-11
- Last Posted Date
- 2018-05-16
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 238
- Registration Number
- NCT00077233
- Locations
- 🇺🇸
Memorial Regional Cancer Center at Memorial Regional Hospital, Hollywood, Florida, United States
🇺🇸MBCCOP - University of Illinois at Chicago, Chicago, Illinois, United States
🇺🇸CCOP - Northern Indiana CR Consortium, South Bend, Indiana, United States
Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast Cancer
- Conditions
- First Posted Date
- 2004-02-09
- Last Posted Date
- 2020-07-14
- Target Recruit Count
- 12
- Registration Number
- NCT00003086
- Locations
- 🇺🇸
Louisiana State University School of Medicine, Shreveport, Louisiana, United States
Surgery Plus Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Urinary Tract
- First Posted Date
- 2004-02-03
- Last Posted Date
- 2021-02-21
- Lead Sponsor
- UNICANCER
- Target Recruit Count
- 53
- Registration Number
- NCT00006111
- Locations
- 🇫🇷
Centre Oscar Lambret, Lille, France
🇫🇷Centre Leon Berard, Lyon, France
🇫🇷Institut Sainte Catherine, Avignon, France
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
- Conditions
- First Posted Date
- 2004-02-02
- Last Posted Date
- 2021-02-17
- Lead Sponsor
- UNICANCER
- Registration Number
- NCT00006050
- Locations
- 🇫🇷
Institut J. Paoli and I. Calmettes, Marseille, France
🇫🇷Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier, France
🇫🇷Institut Gustave Roussy, Villejuif, France
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer
- Conditions
- First Posted Date
- 2004-01-29
- Last Posted Date
- 2018-07-09
- Target Recruit Count
- 359
- Registration Number
- NCT00003888
- Locations
Institute of Oncology and Radiology of Serbia, Belgrade, Former Yugoslavia
🇫🇷CHR de Besancon - Hopital Jean Minjoz, Besancon, France
🇫🇷Centre Hospital Regional Universitaire de Limoges, Limoges, France
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
- Conditions
- First Posted Date
- 2004-01-23
- Last Posted Date
- 2012-07-02
- Target Recruit Count
- 554
- Registration Number
- NCT00003287
- Locations
- 🇬🇷
University Hospital of Heraklion, Iraklion (Heraklion), Crete, Greece
🇫🇷Centre Hospitalier de Montlucon, Montlucon, France
🇫🇷Hopital Notre-Dame de Bon Secours, Metz, France
Chemotherapy, Surgery, and Radiation Therapy in Treating Patients With Gastric Cancer
- Conditions
- Interventions
- First Posted Date
- 2004-01-23
- Last Posted Date
- 2023-07-06
- Lead Sponsor
- ECOG-ACRIN Cancer Research Group
- Target Recruit Count
- 39
- Registration Number
- NCT00003298
- Locations
- 🇺🇸
New England Medical Center Hospital, Boston, Massachusetts, United States
🇺🇸CCOP - Colorado Cancer Research Program, Inc., Denver, Colorado, United States
🇺🇸Indiana University Cancer Center, Indianapolis, Indiana, United States
Drug Development Updates
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