Paclitaxel

Generic Name: Paclitaxel

Brand Names: Abraxane, Taxol, Naveruclif, Pazenir, Apexelsin

Drug Type: Small Molecule

Chemical Formula: C_₄₇H_₅₁NO_₁₄

CAS Number: 33069-62-4

Unique Ingredient Identifier: P88XT4IS4D

Background: Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the n...

Indication: Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.

Associated Conditions: Advanced Cervical Cancer, Advanced Head and Neck Cancer, Advanced Ovarian Cancer, Advanced Soft Tissue Sarcoma, Esophageal Cancer, Fallopian Tube Cancer, Gastric Cancer, Kaposi's Sarcoma, Locally Advanced Non-Small Cell Lung Cancer, Metastatic Bladder Cancer, Metastatic Breast Cancer, Metastatic Melanoma, Metastatic Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Ovarian Cancer, Pancreatic Adenocarcinoma Metastatic, Peritoneal Cancer, Recurrent Small Cell Lung Cancer (SCLC), Advanced Bladder cancer, Advanced Thymoma, Metastatic Penile cancer, Refractory Testicular germ cell cancer

Associated Therapies: -

Clinical Trials

Combination Chemotherapy and Computer-Planned Radiation Therapy in Treating Patients With Unresectable Stage III Non-Small Cell Lung Cancer

Phase 2

Completed

Conditions: Lung Cancer

Interventions: Drug: carboplatin
Drug: gemcitabine hydrochloride
Drug: paclitaxel
Radiation: radiation therapy

First Posted Date: 2003-01-27

Last Posted Date: 2016-07-19

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 69

Registration Number: NCT00033553

Locations: 🇺🇸
Lombardi Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States
🇺🇸
Walter Reed Army Medical Center, Washington, District of Columbia, United States
🇺🇸
Veterans Affairs Medical Center - Washington, DC, Washington, District of Columbia, United States

and more 71 locations

Chemotherapy, Hormone Therapy, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer

Interventions: Drug: carboplatin
Drug: estramustine
Drug: paclitaxel
Radiation: radiation therapy
Drug: leuprolide or goserelin acetate

First Posted Date: 2003-01-27

Last Posted Date: 2016-07-06

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 34

Registration Number: NCT00016913

Locations: 🇺🇸
Walter Reed Army Medical Center, Washington, District of Columbia, United States
🇺🇸
Bon Secours St. Francis Health System, Greenville, South Carolina, United States
🇺🇸
CCOP - Greenville, Greenville, South Carolina, United States

and more 20 locations

Paclitaxel Plus Radiation Therapy in Treating Women With Stage II or Stage III Breast Cancer

Phase 2

Completed

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2023-11-30

Lead Sponsor: Case Comprehensive Cancer Center

Target Recruit Count: 44

Registration Number: NCT00006256

Locations: 🇺🇸
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸
UH-Geauga, Chardon, Ohio, United States
🇺🇸
UH-Monarch, Mayfield Heights, Ohio, United States

and more 6 locations

S0009 Combination Chemo and Surgery in Stage III or Stage IV Ovarian Cancer

Phase 2

Completed

Conditions: Peritoneal Cavity Cancer
Ovarian Cancer
Fallopian Tube Cancer

Interventions: Drug: carboplatin
Drug: paclitaxel
Procedure: debulking surgery

First Posted Date: 2003-01-27

Last Posted Date: 2016-01-08

Lead Sponsor: SWOG Cancer Research Network

Target Recruit Count: 62

Registration Number: NCT00008138

Chemotherapy and Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Stomach Who Have Undergone Surgery

Phase 2

Completed

Conditions: Gastric Cancer
Esophageal Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2015-11-17

Lead Sponsor: Radiation Therapy Oncology Group

Registration Number: NCT00011960

Locations: 🇺🇸
Yale Comprehensive Cancer Center, New Haven, Connecticut, United States
🇺🇸
Providence Alaska Medical Center, Anchorage, Alaska, United States
🇺🇸
John F. Kennedy Medical Center, Edison, New Jersey, United States

and more 66 locations

Combination Chemotherapy Plus Biological Therapy in Treating Patients With Stage II or Stage III Breast Cancer

Phase 1

Withdrawn

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2015-05-05

Lead Sponsor: Roger Williams Medical Center

Registration Number: NCT00022230

Locations: 🇺🇸
Roger Williams Medical Center, Providence, Rhode Island, United States

Paclitaxel and Hyperthermic Perfusion in Treating Patients With Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery

Phase 1

Completed

Conditions: Metastatic Cancer
Lung Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2015-04-29

Lead Sponsor: National Cancer Institute (NCI)

Registration Number: NCT00020007

Locations: 🇺🇸
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland, United States
🇺🇸
NCI - Center for Cancer Research, Bethesda, Maryland, United States

Paclitaxel Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma

Phase 1

Terminated

Conditions: Brain and Central Nervous System Tumors

First Posted Date: 2003-01-27

Last Posted Date: 2015-03-19

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 11

Registration Number: NCT00031577

Locations: 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸
Winship Cancer Institute of Emory University, Egleston, Georgia, United States

Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium and Decreased Kidney Function

Phase 2

Completed

Conditions: Transitional Cell Cancer of the Renal Pelvis and Ureter
Bladder Cancer
Urethral Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2023-06-22

Lead Sponsor: Eastern Cooperative Oncology Group

Registration Number: NCT00005644

Locations: 🇺🇸
Ireland Cancer Center, Cleveland, Ohio, United States
🇺🇸
Albert Einstein Clinical Cancer Center, Bronx, New York, United States
🇺🇸
University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States

and more 13 locations

Paclitaxel and Carboplatin in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Phase 2

Completed

Conditions: Prostate Cancer

Interventions: Drug: carboplatin
Drug: paclitaxel

First Posted Date: 2003-01-27

Last Posted Date: 2020-09-01

Lead Sponsor: Jonsson Comprehensive Cancer Center

Target Recruit Count: 58

Registration Number: NCT00049257

Locations: 🇺🇸
Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States

Drug Development Updates

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