DeepMed Research

Perfluorobutane

Generic Name: Perfluorobutane

Drug Type: Small Molecule

Chemical Formula: C_₄F_₁₀

CAS Number: 355-25-9

Unique Ingredient Identifier: SE4TWR0K2C

Background: Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.

Indication: 适用于肝脏肿块病变的超声显影。

Clinical Trials

Gynecological Sentinel Lymph Nodes CEUS

Early Phase 1

Completed

Conditions: Malignant Female Reproductive System Neoplasm
Vaginal Carcinoma
Vulvar Carcinoma
Cervical Carcinoma

Interventions: Drug: Perflubutane Microbubble
Procedure: Contrast-Enhanced Ultrasound

First Posted Date: 2021-11-03

Last Posted Date: 2025-04-24

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 5

Registration Number: NCT05105087

Locations: 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Role of Perfluorobutane in Lesion Detection, Targeting and Response Assessment for Ablation of HCC

Not Applicable

Completed

Conditions: Microwave Ablation
Hepatocellular Carcinoma

Interventions: Drug: Perfluorobutane

First Posted Date: 2021-10-05

Last Posted Date: 2021-12-21

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 21

Registration Number: NCT05068076

Locations: 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

A Prospective Multi-center Study on Using Sonazoid Diagnose Early Stage Endometrial Cancer

Conditions: Endometrial Carcinoma Stage I

First Posted Date: 2021-07-14

Last Posted Date: 2021-07-14

Lead Sponsor: Chinese PLA General Hospital

Target Recruit Count: 277

Registration Number: NCT04961775

Locations: 🇨🇳
Chinese PLA General Hospital, Beijing, Beijing, China

Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC

Phase 3

Conditions: Hepatocellular Carcinoma
Cirrhosis

Interventions: Drug: Sonovue and Sonazoid
Drug: Sonazoid and Sonovue

First Posted Date: 2019-07-05

Last Posted Date: 2019-09-19

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 100

Registration Number: NCT04006275

Locations: 🇨🇳
Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China

Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer

Early Phase 1

Completed

Conditions: Esophagus

Interventions: Procedure: Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA)
Procedure: Contrast-Enhanced Ultrasound
Procedure: Fine-Needle Aspiration
Drug: Sonazoid (Perflubutane)

First Posted Date: 2018-07-06

Last Posted Date: 2025-05-18

Lead Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University

Target Recruit Count: 35

Registration Number: NCT03578224

Locations: 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Noninvasive Real-time Intracardiac Pressure Measurements Using Subharmonic Ultrasound

Phase 2

Completed

Conditions: Cardiac Catheterization
Blood Pressure
Heart Ventricles
Echocardiography
Heart Failure

Interventions: Drug: Sonazoid

First Posted Date: 2017-08-10

Last Posted Date: 2024-05-29

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 80

Registration Number: NCT03245255

Locations: 🇺🇸
Thomas Jefferson University and Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Ischemic Memory Imaging With Myocardial Contrast Echocardiography

Early Phase 1

Conditions: Myocardial Ischemia

Interventions: Drug: Sonazoid

First Posted Date: 2017-01-04

Last Posted Date: 2018-08-23

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 40

Registration Number: NCT03009266

Locations: 🇺🇸
OHSU, Portland, Oregon, United States

Sonazoid-Enhanced Ultrasound in Detecting Sentinel Lymph Node in Patients With Cutaneous Melanoma

Phase 1

Terminated

Conditions: Cutaneous Melanoma
Melanoma

Interventions: Procedure: Sentinel Lymph Node Biopsy
Device: Ultrasonography
Drug: Sonazoid

First Posted Date: 2016-11-18

Last Posted Date: 2020-03-30

Lead Sponsor: University of Southern California

Target Recruit Count: 5

Registration Number: NCT02968680

Locations: 🇺🇸
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Superb Microvascular Imaging in Focal Nodular Hyperplasia

Not Applicable

Completed

Conditions: Focal Nodular Hyperplasia

Interventions: Drug: Sonazoid
Device: Superb-Microvascular imaging

First Posted Date: 2016-04-14

Last Posted Date: 2019-12-17

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 62

Registration Number: NCT02737865

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Contrast Enhanced Ultrasonography to Detect Human Renal Transplant Rejection

Phase 2

Completed

Conditions: Renal Transplant Rejection

Interventions: Drug: Sonazoid
Device: contrast enhanced ultrasonography

First Posted Date: 2016-04-11

Last Posted Date: 2023-03-06

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 8

Registration Number: NCT02733029

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

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