Carvedilol

Generic Name: Carvedilol

Brand Names: Coreg

Drug Type: Small Molecule

Chemical Formula: C_₂₄H_₂₆N_₂O_₄

CAS Number: 72956-09-3

Unique Ingredient Identifier: 0K47UL67F2

Background: Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.

Carvedilol was granted FDA approval on 14 September 1995.

Indication: Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.

Associated Conditions: Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)

Associated Therapies: -

Clinical Trials

Can MRI Evaluate Beta-blocker Response in Portal Hypertension?

Conditions: Liver Cirrhosis
Portal Hypertension
Varix, Esophageal

Interventions: Drug: Carvedilol
Other: MRI scan
Procedure: Hepatic Venous Pressure Gradient (HVPG)

First Posted Date: 2017-04-14

Last Posted Date: 2018-05-08

Lead Sponsor: University of Nottingham

Target Recruit Count: 68

Registration Number: NCT03114813

Locations: 🇬🇧
NIHR Nottingham Biomedical Research Centre, Nottingham, Nottinghamshire, United Kingdom
🇬🇧
University of Nottingham, Nottingham, United Kingdom

Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis

Not Applicable

Conditions: Cirrhosis

Interventions: Drug: Carvedilol
Procedure: Endoscopic Variceal Ligation

First Posted Date: 2017-03-03

Last Posted Date: 2020-02-19

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 330

Registration Number: NCT03069339

Locations: 🇮🇳
Institute of liver and Biliary Sciences, New Delhi, Delhi, India

A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging

Phase 2

Active, not recruiting

Conditions: HER2 Positive Breast Cancer
Cardiovascular Abnormalities

Interventions: Drug: Carvedilol

First Posted Date: 2016-12-15

Last Posted Date: 2024-06-03

Lead Sponsor: Northwestern University

Target Recruit Count: 134

Registration Number: NCT02993198

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

Doppler Ultrasound Hepatic Vein Waveform as a Non-invasive Tool in the Assessment of Severity of Portal Hypertension

Phase 3

Conditions: Portal Hypertension

Interventions: Drug: Carvedilol

First Posted Date: 2016-11-29

Last Posted Date: 2016-12-05

Lead Sponsor: Aga Khan University

Target Recruit Count: 50

Registration Number: NCT02975323

Locations: 🇵🇰
Aga Khan University,, Karachi, Sind, Pakistan

Effect of Carvedilol on Exercise Performance in Fontan Patients

Phase 4

Completed

Conditions: Single Ventricle
Fontan

Interventions: Drug: Carvedilol
Drug: Placebo

First Posted Date: 2016-10-27

Last Posted Date: 2021-01-22

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 26

Registration Number: NCT02946892

Locations: 🇺🇸
University of Texas Southwestern, Dallas, Texas, United States

Beta Adrenergic Receptor Blockade as a Novel Therapy for Patients With Adenocarcinoma of the Prostate

Phase 2

Conditions: Prostate Cancer

Interventions: Drug: Carvedilol

First Posted Date: 2016-10-25

Last Posted Date: 2021-02-21

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 22

Registration Number: NCT02944201

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS

Phase 4

Conditions: Cirrhosis
Portal Hypertension

Interventions: Device: 3D-vHPS
Drug: Carvedilol
Procedure: Routine endoscopic procedures

First Posted Date: 2016-10-06

Last Posted Date: 2020-02-25

Lead Sponsor: Changqing Yang

Target Recruit Count: 100

Registration Number: NCT02925975

Locations: 🇨🇳
Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Spironolactone on Fibrosis Progrssion-Portal Hypertension(FP-PH)in Cirrhosis

Phase 4

Completed

Conditions: Cirrhosis
Portal Hypertension

Interventions: Drug: Carvedilol
Drug: Spironolactone and carvedilol

First Posted Date: 2016-09-20

Last Posted Date: 2020-08-25

Lead Sponsor: Changqing Yang

Target Recruit Count: 96

Registration Number: NCT02907749

Locations: 🇨🇳
Shanghai Tongji Hospital, Tongji University, Shanghai, Shanghai, China

Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome

Phase 4

Completed

Conditions: Acute Coronary Syndrome

Interventions: Drug: Carvedilol
Drug: Metoprolol

First Posted Date: 2016-06-22

Last Posted Date: 2022-03-31

Lead Sponsor: Federico II University

Target Recruit Count: 100

Registration Number: NCT02809820

Locations: 🇮🇹
Federico II University of Naples, Naples, Italy

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

Phase 2

Active, not recruiting

Conditions: Malignant Solid Neoplasm
Hematopoietic and Lymphoid Cell Neoplasm

Interventions: Drug: Carvedilol
Other: Laboratory Biomarker Analysis
Other: Pharmacological Study
Other: Pharmacogenomic Study
Other: Placebo Administration
Other: Quality-of-Life Assessment
Other: Questionnaire Administration

First Posted Date: 2016-03-23

Last Posted Date: 2024-04-09

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 196

Registration Number: NCT02717507

Locations: 🇺🇸
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States
🇺🇸
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois, United States
🇺🇸
Saint Mary's Hospital, West Palm Beach, Florida, United States

and more 88 locations

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