Carvedilol
- Generic Name
- Carvedilol
- Brand Names
- Coreg
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26N2O4
- CAS Number
- 72956-09-3
- Unique Ingredient Identifier
- 0K47UL67F2
- Background
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs ...
- Indication
Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.
- Associated Conditions
- Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)
- Associated Therapies
- -
The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2016-03-01
- Last Posted Date
- 2016-03-01
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 792
- Registration Number
- NCT02695732
- Locations
- 🇨🇳
Zhongshan Hospital, Shanghai, China
The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices
- Conditions
- Interventions
- First Posted Date
- 2015-12-23
- Last Posted Date
- 2015-12-23
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 500
- Registration Number
- NCT02638415
- Locations
- 🇨🇳
Shanghai Zhongshan Hospital, Shanghai, Shanghai, China
Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients
- First Posted Date
- 2015-12-02
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- Dong-A University
- Target Recruit Count
- 62
- Registration Number
- NCT02619526
- Locations
- 🇰🇷
Department of Internal Medicine,Dong-A University College of Medicine, Busan, Korea, Republic of
Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices
- Conditions
- Interventions
- First Posted Date
- 2015-10-22
- Last Posted Date
- 2019-06-04
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 136
- Registration Number
- NCT02583698
- Locations
- 🇮🇳
Institute of liver and Biliary Sciences, New Delhi, Delhi, India
Comparison of Carvedilol and Atenolol on Anti-anginal and Metabolic Effects in Patients With Stable Angina Pectoris
- First Posted Date
- 2015-09-11
- Last Posted Date
- 2015-09-11
- Lead Sponsor
- Gachon University Gil Medical Center
- Target Recruit Count
- 99
- Registration Number
- NCT02547597
- Locations
- 🇰🇷
Gachon University Gil Medical Center, Incheon, Korea, Republic of
Beta-blockers in Pulmonary Arterial Hypertension
- Conditions
- Interventions
- First Posted Date
- 2015-07-23
- Last Posted Date
- 2020-06-16
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 2
- Registration Number
- NCT02507011
- Locations
- 🇺🇸
University of Minnesota Medical Center, Minneapolis, Minnesota, United States
Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2015-07-22
- Last Posted Date
- 2017-08-21
- Lead Sponsor
- Kaohsiung Veterans General Hospital.
- Target Recruit Count
- 121
- Registration Number
- NCT02504723
- Locations
- 🇨🇳
Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.
- Conditions
- Interventions
- First Posted Date
- 2015-06-08
- Last Posted Date
- 2018-05-11
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 220
- Registration Number
- NCT02465645
- Locations
- 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India
Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)
- Conditions
- Interventions
- First Posted Date
- 2015-04-02
- Last Posted Date
- 2019-01-08
- Lead Sponsor
- Emory University
- Target Recruit Count
- 36
- Registration Number
- NCT02406586
- Locations
- 🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2015-03-11
- Last Posted Date
- 2015-03-11
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 480
- Registration Number
- NCT02385422
- Locations
- 🇨🇳
Shanghai Zhongshan Hospital, Shanghai, Shanghai, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.