Dapivirine
- Generic Name
- Dapivirine
- Drug Type
- Small Molecule
- Chemical Formula
- C20H19N5
- CAS Number
- 244767-67-7
- Unique Ingredient Identifier
- TCN4MG2VXS
- Background
Dapivirine has been investigated for the prevention of HIV-1 Infections and Topical Penile Exposures.
Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures
- Conditions
- Topical Penile Exposures
- Interventions
- First Posted Date
- 2011-01-17
- Last Posted Date
- 2017-09-08
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 48
- Registration Number
- NCT01277640
- Locations
- πΊπΈ
University of Alabama at Birmingham, Birmingham, Alabama, United States
πΊπΈUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
A Safety and Pharmacokinetic Study for Dapivirine and Maraviroc Gel in Belgium
- Conditions
- HIV Infections
- Interventions
- Drug: Matching Placebo GelDrug: Maraviroc/Dapivirine Gel
- First Posted Date
- 2010-11-17
- Last Posted Date
- 2011-09-09
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Registration Number
- NCT01242579
A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring
- First Posted Date
- 2010-06-15
- Last Posted Date
- 2010-10-06
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 45
- Registration Number
- NCT01144676
- Locations
- π§πͺ
SGS Life Science Services, Antwerp, Flanders, Belgium
An Expanded Safety Study of Dapivirine Gel 4759 in Africa
- Conditions
- HIV InfectionsAcquired Immunodeficiency Syndrome
- Interventions
- Drug: placebo
- First Posted Date
- 2009-06-10
- Last Posted Date
- 2011-09-12
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 280
- Registration Number
- NCT00917891
- Locations
- πΏπ¦
Desmond Tutu HIV Foundation, Nyanga, Cape Town, Western Cape, South Africa
πΏπ¦Madibeng Centre for Research, Brits, North West Province, South Africa
π°πͺKenya Medical Research Institute, Kisumu, Kenya
An Expanded Safety Study of Dapivirine Gel 4789 in Africa
- Conditions
- HIV InfectionsAcquired Immunodeficiency SyndromeHealthy
- Interventions
- Drug: placebo
- First Posted Date
- 2009-06-10
- Last Posted Date
- 2011-12-14
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 100
- Registration Number
- NCT00917904
- Locations
- πΏπ¦
Be Part Clinic, Mbekweni, Paarl, Eastern Cape, South Africa
πΏπ¦Desmond Tutu HIV Foundation, Masiphumelele, Cape Town, Western Cape, South Africa
πΏπ¦Madibeng Centre for Research, Brits, North West Province, South Africa
A Safety Study of Two Dapivirine (TMC120) Vaginal Gels in the United States
- Conditions
- HIV-1 Infections
- Interventions
- First Posted Date
- 2008-11-27
- Last Posted Date
- 2022-10-25
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 128
- Registration Number
- NCT00799058
- Locations
- πΊπΈ
Harbor-UCLA Medical Center, Torrance, California, United States
πΊπΈUniversity of Illinois at Chicago, Chicago, Illinois, United States
πΊπΈSNBL Clinical Pharmacology Center, Baltimore, Maryland, United States
A Phase I Pharmacokinetics and Safety Study of Two Dapivirine Intravaginal Gels
- Conditions
- HIV Infections
- Interventions
- Drug: HEC-based Placebo Gel
- First Posted Date
- 2008-02-13
- Last Posted Date
- 2009-03-27
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT00613249
- Locations
- π§πͺ
SGS Life Science Services Research Unit Stuivenberg, Antwerp, Belgium
A Pharmacokinetic Study of Dapivirine Vaginal Rings in Belgium
- Conditions
- HIV Infections
- Interventions
- Other: placebo intravaginal ring
- First Posted Date
- 2007-05-04
- Last Posted Date
- 2009-09-01
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT00469768
- Locations
- π§πͺ
Drug Research Unit Ghent (D.R.U.G.), Ghent, Belgium
Safety and Feasibility Study of Dapivirine (TMC120) Vaginal Ring in Belgium
- Conditions
- HIV Infections
- First Posted Date
- 2006-06-02
- Last Posted Date
- 2009-09-01
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 13
- Registration Number
- NCT00332995
- Locations
- π§πͺ
Drug Research Unit Gent, Gent, Belgium
A Safety Study of Dapivirine (TMC120) Vaginal Microbicide Gel in Belgium
- Conditions
- HIV InfectionsHIV-1
- First Posted Date
- 2006-03-31
- Last Posted Date
- 2009-09-01
- Lead Sponsor
- International Partnership for Microbicides, Inc.
- Target Recruit Count
- 36
- Registration Number
- NCT00309205
- Locations
- π§πͺ
SGS Biopharma - Research Unit Stuivenberg, Antwerp, Belgium
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