利福平 (Isonarif, Rifadin, Rifamate +2)

概览

Rifampicin is an antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.

作用机制

Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

适应症

Rifampin is indicated for the treatment of tuberculosis and tuberculosis-related mycobacterial infections. In combination with pyrazinamide and isoniazid, it is used in the initial phase of the short-course treatment of pulmonary tuberculosis.

• Cholestatic pruritus
• MRSA Infections
• Prosthetic Joint Infections
• Asymptomatic Neisseria meningitidis carrier of the nasopharynx
• Initial phase Tuberculosis
• Late phase Tuberculosis