Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.
Azathiprine was granted FDA approval on 20 March 1968.
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy.
- Conditions
- Heart FailureImmunosuppressionMyocarditisEndomyocardial BiopsyCardiomyopathies, Secondary
- Interventions
- First Posted Date
- 2020-12-04
- Last Posted Date
- 2024-03-28
- Lead Sponsor
- Medical University of Warsaw
- Target Recruit Count
- 100
- Registration Number
- NCT04654988
- Locations
- 🇵🇱
First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Early Use of Long-acting Tacrolimus in Lung Transplant Recipients
- Conditions
- Lung Transplant; Complications
- Interventions
- First Posted Date
- 2020-07-14
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 48
- Registration Number
- NCT04469842
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery
- Conditions
- Crohn Disease
- Interventions
- Dietary Supplement: postoperative 3-month exclusive enteral nutritionOther: normal diet
- First Posted Date
- 2019-11-13
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- Zhu Weiming
- Target Recruit Count
- 54
- Registration Number
- NCT04160325
- Locations
- 🇨🇳
Department of General Surgery, Jinling hosptal,Medical School of Nanjing University, Nanjing, Jiangsu, China
Bioequivalence of Azathioprine Suspension 10 mg/mL (Jayempi) Versus Azathioprine Tablet 50mg (Imurek®)
- Conditions
- Therapeutic Equivalency
- Interventions
- First Posted Date
- 2019-04-29
- Last Posted Date
- 2021-06-22
- Lead Sponsor
- Nova Laboratories Limited
- Target Recruit Count
- 30
- Registration Number
- NCT03930264
- Locations
- 🇬🇧
Nova Laboratories Limited, Leicester, Leicestershire, United Kingdom
🇬🇧Medicines Evaluation Unit Ltd Southmoor Road, Manchester, United Kingdom
Multicenter Registry of Pediatric Lupus Nephritis in China
- Conditions
- Lupus NephritisChildrenSteroidImmunosuppressive Treatment
- Interventions
- First Posted Date
- 2019-01-03
- Last Posted Date
- 2019-04-05
- Lead Sponsor
- Xiqiang Dang
- Target Recruit Count
- 1200
- Registration Number
- NCT03791827
- Locations
- 🇨🇳
The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Post-Operative Crohn's Disease Outcome in Children
- First Posted Date
- 2018-09-24
- Last Posted Date
- 2025-05-15
- Lead Sponsor
- Schneider Children's Medical Center, Israel
- Target Recruit Count
- 100
- Registration Number
- NCT03681652
- Locations
- 🇮🇱
Schneider Children's Hospital, Petach Tikva, Israel
Addition of Azathioprine in IBD Patients With Immunogenic Failure
- Conditions
- Clinical Failure After Switch
- Interventions
- Drug: Switch to a second anti-TNF drug alone
- First Posted Date
- 2018-07-09
- Last Posted Date
- 2018-07-10
- Lead Sponsor
- Védrines, Philippe, M.D.
- Target Recruit Count
- 90
- Registration Number
- NCT03580876
- Locations
- 🇫🇷
Clinic of Montbrison, Montbrison, Loire, France
Azathioprine in Recurrent Implantation Failure
- Conditions
- Recurrent Implantation FailureIn Vitro FertilizationIntracytoplsmic Sperm Injection
- Interventions
- Drug: Placebo Oral Tablet
- First Posted Date
- 2018-04-17
- Last Posted Date
- 2019-07-24
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 64
- Registration Number
- NCT03498703
- Locations
- 🇪🇬
Ain Shams University, Maternity Hospital, Cairo, Egypt
🇪🇬Capital Birth Center, Cairo, Egypt
Disease-Modifying Treatments for Myasthenia Gravis
- Conditions
- Neurological DisorderAutoimmune Diseases
- Interventions
- First Posted Date
- 2018-04-06
- Last Posted Date
- 2021-02-03
- Lead Sponsor
- Duke University
- Target Recruit Count
- 167
- Registration Number
- NCT03490539
- Locations
- 🇨🇦
University of Alberta Hospital, Faculty of Medicine, Edmonton, Alberta, Canada
🇺🇸University at Buffalo, SUNY, Buffalo, New York, United States
🇺🇸University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis
- Conditions
- Rheumatoid Arthritis
- Interventions
- First Posted Date
- 2018-02-28
- Last Posted Date
- 2022-04-28
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 84
- Registration Number
- NCT03449758
- Locations
- 🇫🇷
Investigational Site Number 250014, Caen, France
🇫🇷Investigational Site Number 250006, Besancon, France
🇫🇷Investigational Site Number 250016, Bordeaux, France
Drug Development Updates
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