Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia
- Conditions
- Interventions
- First Posted Date
- 2017-07-26
- Last Posted Date
- 2018-06-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 40
- Registration Number
- NCT03229746
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
Effectiveness of Rifaximin Combined With Thiopurine on Preventing Postoperative Recurrence in Crohn's Disease
- First Posted Date
- 2017-06-14
- Last Posted Date
- 2017-06-14
- Target Recruit Count
- 120
- Registration Number
- NCT03185611
- Locations
- 🇨🇳
The Sixth Affiliated Hospital, Sun Yat-sen University, Guanzhou, Guangdong, China
Maintenance of Remission with Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis with Polyangiitis.
- Conditions
- Interventions
- First Posted Date
- 2017-05-23
- Last Posted Date
- 2024-10-18
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 98
- Registration Number
- NCT03164473
- Locations
- 🇫🇷
Hôpital Cochin, Paris, France
Two Therapeutic Strategies for the Maintenance of Remission in Patients With Ulcerative Colitis
- First Posted Date
- 2017-05-12
- Last Posted Date
- 2017-05-12
- Lead Sponsor
- Istituto Clinico Humanitas
- Target Recruit Count
- 100
- Registration Number
- NCT03151525
- Locations
- 🇮🇹
IBD Center, Rozzano, MI, Italy
Beneficial and Harmful Effects of Azathioprine and Allopurinol Versus Standard Azathioprine Therapy for Patients With Ulcerative Colitis
- Conditions
- Interventions
- First Posted Date
- 2017-04-05
- Last Posted Date
- 2018-08-15
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 84
- Registration Number
- NCT03101800
- Locations
- 🇩🇰
Hvidovre university hospital, Hvidovre, Denmark
Alitretinoin vs Azathioprine in Severe Non-hyperkeratotic Hand Eczema
- First Posted Date
- 2017-01-20
- Last Posted Date
- 2018-05-04
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 116
- Registration Number
- NCT03026907
- Locations
- 🇳🇱
University Medical Center Groningen, Groningen, Netherlands
Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients
- Conditions
- Interventions
- First Posted Date
- 2016-12-23
- Last Posted Date
- 2020-09-30
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 86
- Registration Number
- NCT03002038
- Locations
- 🇮🇷
Kashani Hospital, Isfahan, Iran, Islamic Republic of
A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis
- Conditions
- Interventions
- First Posted Date
- 2016-12-16
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- ChemoCentryx
- Target Recruit Count
- 331
- Registration Number
- NCT02994927
- Locations
- 🇬🇧
Clinical Trial Site, Westcliff-on-Sea, United Kingdom
Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis
- Conditions
- Interventions
- First Posted Date
- 2016-10-31
- Last Posted Date
- 2017-03-03
- Lead Sponsor
- Genovate Biotechnology Co., Ltd.,
- Target Recruit Count
- 32
- Registration Number
- NCT02949349
A Randomized Multicenter Study for Isolated Skin Vasculitis
- Conditions
- Interventions
- First Posted Date
- 2016-10-20
- Last Posted Date
- 2024-02-01
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 90
- Registration Number
- NCT02939573
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸Boston University School of Medicine, Boston, Massachusetts, United States
🇺🇸Penn State Hershey Medical Center, Hershey, Pennsylvania, United States
Drug Development Updates
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