Proguanil
- Generic Name
- Proguanil
- Brand Names
- Malarone
- Drug Type
- Small Molecule
- Chemical Formula
- C11H16ClN5
- CAS Number
- 500-92-5
- Unique Ingredient Identifier
- S61K3P7B2V
- Background
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
- Indication
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
- Associated Conditions
- Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum
- Associated Therapies
- -
First participants dosed in trial of long-acting malaria preventative
MMV and Quotient Sciences have dosed first participants in a trial of MMV371, a long-acting injectable for malaria prevention, aiming for up to three months of protection with a single dose. The Phase I trial will evaluate safety, tolerability, and pharmacokinetics, with clinical trials in malaria-endemic countries expected to begin in 2026. The final injectable will combine MMV371 with a partner drug to reduce resistance.
Drug Development Updates
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