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A Study of Different Forms of BGB-43395 and Food Effect in Healthy Participants

Phase 1
Recruiting
Conditions
Healthy Volunteers
Interventions
First Posted Date
2025-01-07
Last Posted Date
2025-04-11
Lead Sponsor
BeiGene
Target Recruit Count
48
Registration Number
NCT06761898
Locations
🇺🇸

Fortrea Cru, Daytone Beach, Daytona Beach, Florida, United States

BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

Phase 1
Recruiting
Conditions
Hormone-receptor-positive Breast Cancer
HER2-negative Breast Cancer
Metastatic Breast Cancer
Interventions
First Posted Date
2025-01-03
Last Posted Date
2025-05-09
Lead Sponsor
BeiGene
Target Recruit Count
92
Registration Number
NCT06756932
Locations
🇺🇸

Hoag Memorial Presbyterian, Newport Beach, California, United States

🇺🇸

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

🇺🇸

Md Anderson Cancer Center, Houston, Texas, United States

and more 12 locations

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

Phase 1
Recruiting
Conditions
Breast Cancer
Small Cell Lung Cancer
Ovarian Cancer
Gastric Cancer
Hormone-receptor-positive Breast Cancer
Hormone Receptor Positive HER-2 Negative Breast Cancer
Advanced Solid Tumor
Endometrial Cancer
Prostate Cancer
TNBC - Triple-Negative Breast Cancer
Interventions
First Posted Date
2024-02-13
Last Posted Date
2025-05-20
Lead Sponsor
BeiGene
Target Recruit Count
218
Registration Number
NCT06257264
Locations
🇨🇳

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China

🇺🇸

Hoag Memorial Presbyterian, Newport Beach, California, United States

🇺🇸

Florida Cancer Specialists and Research Institute, Lake Mary, Florida, United States

and more 30 locations

BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Phase 1
Active, not recruiting
Conditions
Advanced Solid Tumor
Metastatic Solid Tumor
Hormone-receptor-positive Breast Cancer
Breast Cancer
Metastatic Breast Cancer
Hormone Receptor Positive Malignant Neoplasm of Breast
HER2-negative Breast Cancer
Interventions
First Posted Date
2024-02-12
Last Posted Date
2025-05-20
Lead Sponsor
BeiGene
Target Recruit Count
33
Registration Number
NCT06253195
Locations
🇨🇳

Beijing Cancer Hospital, Beijing, Beijing, China

🇨🇳

Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China

🇨🇳

Fujian Cancer Hospital, Fuzhou, Fujian, China

and more 4 locations

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

Phase 1
Recruiting
Conditions
Advanced Solid Tumor
Hormone Receptor Positive Malignant Neoplasm of Breast
Advanced Breast Cancer
Metastatic Breast Cancer
Hormone-receptor-positive Breast Cancer
HER2-negative Breast Cancer
Hormone Receptor Positive HER-2 Negative Breast Cancer
Non-small Cell Lung Cancer
Hormone Receptor Positive Breast Carcinoma
Interventions
First Posted Date
2023-11-07
Last Posted Date
2025-05-09
Lead Sponsor
BeiGene
Target Recruit Count
79
Registration Number
NCT06120283
Locations
🇧🇷

Fundacao Universidade de Caxias Do Sul Instituto de Pesquisas Em Saude, Petropolis, Brazil

🇧🇷

Hospital Sao Lucas Da Pucrs Uniao Brasileira de Educacao E Assistencia, Porto Algre, Brazil

🇺🇸

Sarah Cannon Research Institute (Scri) At Health One, Denver, Colorado, United States

and more 124 locations
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