Lithium cation
- Generic Name
- Lithium cation
- Drug Type
- Small Molecule
- Chemical Formula
- Li
- CAS Number
- 7439-93-2
- Unique Ingredient Identifier
- 8H8Z5UER66
- Background
Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
- Indication
Lithium, in its salt forms, is used as a mood stabilizer and for the treatment of depression and mania. It is most frequently prescribed in the treatment of bipolar disorder.
- Associated Conditions
- Bipolar Disorder (BD), Depression, Depression, Bipolar, Acute Manic episode
Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients
- First Posted Date
- 2012-10-19
- Last Posted Date
- 2012-10-19
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 50
- Registration Number
- NCT01710163
- Locations
- 🇧🇷
Institute of Psychiatry, University of São Paulo, São Paulo, Brazil
🇧🇷Institute of Psychiatry, São Paulo, Brazil
Sequential Multiple Assignment Treatment for Bipolar Disorder
- Conditions
- Bipolar I DisorderBipolar II Disorder
- Interventions
- First Posted Date
- 2012-05-01
- Last Posted Date
- 2020-08-19
- Target Recruit Count
- 112
- Registration Number
- NCT01588457
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸University of Texas Health Science Center, San Antonio, Texas, United States
Neural Correlates for Therapeutic Mechanisms of Lithium in Bipolar Disorder
- First Posted Date
- 2012-03-05
- Last Posted Date
- 2018-02-09
- Lead Sponsor
- Ewha Womans University
- Registration Number
- NCT01543724
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Gao Bipolar Spectrum Lithium/Quetiapine Study
- First Posted Date
- 2012-02-03
- Last Posted Date
- 2017-08-16
- Lead Sponsor
- University Hospitals Cleveland Medical Center
- Target Recruit Count
- 42
- Registration Number
- NCT01526148
- Locations
- 🇺🇸
University Hospitals Cleveland Medical Center - Mood Disorders Program, Cleveland, Ohio, United States
A Feasibility Trial Using Lithium As A Neuroprotective Agent In Patients Undergoing Prophylactic Cranial Irradiation For Small Cell Lung Cancer
- First Posted Date
- 2011-12-06
- Last Posted Date
- 2015-03-18
- Lead Sponsor
- Barwon Health
- Target Recruit Count
- 7
- Registration Number
- NCT01486459
- Locations
- 🇦🇺
Barwon Health, Geelong, Victoria, Australia
🇦🇺Peter MacCallum Cancer Centre, Moorabbin, Victoria, Australia
Decision-Making in Bipolar Disorder
- Conditions
- Bipolar Disorder
- Interventions
- First Posted Date
- 2011-11-01
- Last Posted Date
- 2017-05-31
- Lead Sponsor
- Emory University
- Target Recruit Count
- 37
- Registration Number
- NCT01463111
- Locations
- 🇺🇸
Emory University Mood and Anxiety Disorders Program, Atlanta, Georgia, United States
Wake Therapy in the Treatment of Depression
- Conditions
- Bipolar DisorderMajor Depressive Disorder
- Interventions
- First Posted Date
- 2011-09-09
- Last Posted Date
- 2021-03-18
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 8
- Registration Number
- NCT01431573
- Locations
- 🇺🇸
Depression Evaluation Service - New York State Psychiatric Institute, New York, New York, United States
🇺🇸New York State Psychiatric Institute, New York, New York, United States
Lithium Versus Paroxetine in Major Depression
- First Posted Date
- 2011-08-12
- Last Posted Date
- 2020-07-16
- Lead Sponsor
- Nova Scotia Health Authority
- Target Recruit Count
- 2
- Registration Number
- NCT01416220
- Locations
- 🇨🇦
Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Efficacy and Safety of Two Pharmacologic Strategies on Neurocognitive Impairment in HIV Infection. The TRIANT-TE Study
- Conditions
- Neurocognitive DisturbanceHIV Infection
- Interventions
- First Posted Date
- 2011-05-05
- Last Posted Date
- 2014-04-01
- Lead Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
- Target Recruit Count
- 33
- Registration Number
- NCT01348282
- Locations
- 🇪🇸
Fundació LLuita contra la SIDA, Badalona, Barcelona, Spain
Comparative Effectiveness Study for Bipolar Disorder
- First Posted Date
- 2011-04-08
- Last Posted Date
- 2018-04-26
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 482
- Registration Number
- NCT01331304
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
🇺🇸University of Michigan, Ann Arbor, Michigan, United States
🇺🇸Weill Cornell Medical College, New York, New York, United States
Drug Development Updates
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