Esketamine

Generic Name: Esketamine

Brand Names: Spravato

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆ClNO

CAS Number: 33643-46-8

Unique Ingredient Identifier: 50LFG02TXD

Background: Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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Indication: Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.

Associated Conditions: Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain

Associated Therapies: Intubation

Clinical Trials

The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery

Early Phase 1

Recruiting

Conditions: Postoperative Delirium
Elderly Patients

Interventions: Drug: Normal saline
Drug: S-ketamine
Drug: Dexmedetomidine

First Posted Date: 2022-02-16

Last Posted Date: 2023-02-21

Lead Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University

Target Recruit Count: 780

Registration Number: NCT05242692

Locations: 🇨🇳
Cancer hospital and institute of Guangzhou medical university, Guangzhou, Guangdong, China

Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

Not Applicable

Conditions: S-ketamine
Opioid Use, Unspecified

Interventions: Drug: S-ketamine
Drug: Sufentanil

First Posted Date: 2022-02-16

Last Posted Date: 2022-07-20

Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Target Recruit Count: 980

Registration Number: NCT05242081

Locations: 🇨🇳
The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting

Conditions: General Anesthetic
Electroencephalogram

Interventions: Drug: propofol
Drug: S-ketamine
Drug: sevoflurane

First Posted Date: 2022-01-27

Last Posted Date: 2024-03-20

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 366

Registration Number: NCT05210764

Locations: 🇨🇳
Peking University First Hospital, Beijing, China

Intravenous Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac Surgery

Not Applicable

Conditions: Postoperative Depression

Interventions: Drug: Normal saline
Drug: Esketamine

First Posted Date: 2021-12-14

Last Posted Date: 2021-12-14

Lead Sponsor: Anshi Wu

Target Recruit Count: 80

Registration Number: NCT05155969

Locations: 🇨🇳
Beijing Chaoyang Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
Beijing Chaoyang Hospital, Beijing, Beijing, China

Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery

Not Applicable

Conditions: Postoperative Pain

Interventions: Drug: Normal saline
Drug: Compound lidocaine
Drug: Ropivacaine
Drug: Esketamine

First Posted Date: 2021-11-16

Last Posted Date: 2021-11-16

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 160

Registration Number: NCT05122338

The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury

Phase 4

Recruiting

Conditions: Intracerebral Hemorrhage
Traumatic Brain Injury
Subarachnoid Hemorrhage, Aneurysmal

Interventions: Other: Isotonic saline (placebo)
Drug: S-ketamine

First Posted Date: 2021-10-27

Last Posted Date: 2024-06-26

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 400

Registration Number: NCT05095857

Locations: 🇩🇰
Rigshospitalet, Copenhagen, Denmark

Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

Not Applicable

Conditions: Postoperative Hyperalgesia

Interventions: Drug: S-ketamine
Drug: saline

First Posted Date: 2021-08-23

Last Posted Date: 2021-09-29

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 92

Registration Number: NCT05016128

Locations: 🇨🇳
Second affiliated Hospital School of Medicine,Zhejiang University, Hangzhou, Zhejiang, China

Comparison of Sedation by Esketamine and Sevoflurane

Phase 4

Conditions: Sevoflurane

Interventions: Drug: Sevoflurane
Drug: Esketamine

First Posted Date: 2021-08-18

Last Posted Date: 2022-04-05

Lead Sponsor: Eye & ENT Hospital of Fudan University

Target Recruit Count: 60

Registration Number: NCT05011214

Locations: 🇨🇳
Anesthesiology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, Shanghai, China

Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery

Phase 4

Recruiting

Conditions: Spine Fusion
S-ketamine
Postoperative Analgesia

Interventions: Drug: Placebo
Drug: S-ketamine

First Posted Date: 2021-07-16

Last Posted Date: 2024-05-09

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 164

Registration Number: NCT04964219

Locations: 🇨🇳
Beijing University First Hospital, Beijing, Beijing, China

Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery

Not Applicable

Conditions: Sepsis
Acute Lung Injury

Interventions: Other: saline
Drug: S-ketamine

First Posted Date: 2021-05-05

Last Posted Date: 2021-08-31

Lead Sponsor: Tianjin Nankai Hospital

Target Recruit Count: 50

Registration Number: NCT04873479

Locations: 🇨🇳
Tianjin Nankai Hospital, Tianjin, Tianjin, China

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