Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
Esketamine on Postpartum Depression in Cesarean Section Women
- Conditions
- Interventions
- First Posted Date
- 2021-04-27
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Ailin Luo
- Target Recruit Count
- 336
- Registration Number
- NCT04860661
- Locations
- 🇨🇳
Tongji Hospital, Wuhan, Hubei, China
Effect of Low-dose Esketamine on Postoperative Depression in Patients With Breast Cancer
- First Posted Date
- 2021-04-20
- Last Posted Date
- 2022-07-28
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 90
- Registration Number
- NCT04850937
- Locations
- 🇨🇳
Affiliated hospital of yangzhou university, Yangzhou, Jiangsu, China
A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment
- First Posted Date
- 2021-04-02
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Janssen-Cilag Ltd.
- Target Recruit Count
- 183
- Registration Number
- NCT04829318
- Locations
- 🇦🇷
Sanatorio Prof Leon S Morra S A, Cordoba, Argentina
🇦🇷Instituto de Neurociencias San Agustin, La Plata, Argentina
🇨🇿A Shine S R O, Plzen, Czechia
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
- Conditions
- Interventions
- First Posted Date
- 2021-03-10
- Last Posted Date
- 2022-12-13
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04791059
- Locations
- 🇨🇳
Peking University First Hospital, Beijing, Beijing, China
The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy
- First Posted Date
- 2021-03-02
- Last Posted Date
- 2021-07-20
- Target Recruit Count
- 396
- Registration Number
- NCT04777110
Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Anesthetized Patients Accessed by Pulmonary Ultrasound
- First Posted Date
- 2021-02-09
- Last Posted Date
- 2021-02-09
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT04745286
The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision Pediatric Circumcision
- First Posted Date
- 2021-01-06
- Last Posted Date
- 2022-02-10
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 90
- Registration Number
- NCT04698434
- Locations
- 🇨🇳
Affiliated hospital of yangzhou university, Yangzhou, Jiangsu, China
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
- First Posted Date
- 2020-12-31
- Last Posted Date
- 2020-12-31
- Lead Sponsor
- Tianjin Union Medical Center
- Target Recruit Count
- 1000
- Registration Number
- NCT04691076
- Locations
- 🇨🇳
Tianjin Union Medical Center, Tianjin, China
Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients
- First Posted Date
- 2020-12-24
- Last Posted Date
- 2020-12-24
- Target Recruit Count
- 26
- Registration Number
- NCT04682782
- Locations
- 🇨🇳
2nd affiliated hospital, School of Medicine, Zhejiang Universtiy, China, Hangzhou, Zhejiang, China
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia
- First Posted Date
- 2020-12-11
- Last Posted Date
- 2020-12-11
- Target Recruit Count
- 48
- Registration Number
- NCT04664530
- Locations
- 🇨🇳
The Second Affiliated Hospital of Zhejiang University anesthesiology department, Hangzhou, Zhejiang, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.