Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
The Efficacy and Safety of S-ketamine in Elective Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2020-12-08
- Last Posted Date
- 2020-12-08
- Lead Sponsor
- Beijing Obstetrics and Gynecology Hospital
- Target Recruit Count
- 402
- Registration Number
- NCT04657107
Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients
- Conditions
- Interventions
- First Posted Date
- 2020-10-22
- Last Posted Date
- 2022-03-15
- Lead Sponsor
- Peking University
- Target Recruit Count
- 48
- Registration Number
- NCT04597320
- Locations
- 🇨🇳
Peking University Hospital of Stomatology, Beijing, Beijing, China
Imaging Neural Correlates of Ketamine Using PET/MR
- Conditions
- Interventions
- First Posted Date
- 2020-10-14
- Last Posted Date
- 2024-03-04
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 65
- Registration Number
- NCT04587778
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
A Multicenter Study of the Efficacy and Safety of Esketamine for Analgesia During Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2024-12-04
- Target Recruit Count
- 600
- Registration Number
- NCT04548973
- Locations
- 🇨🇳
Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, China
University of Iowa Interventional Psychiatry Service Patient Registry
- Conditions
- Interventions
- First Posted Date
- 2020-07-22
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Mark Niciu
- Target Recruit Count
- 1000
- Registration Number
- NCT04480918
- Locations
- 🇺🇸
University of Iowa Health Care, Iowa City, Iowa, United States
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
- First Posted Date
- 2020-07-20
- Last Posted Date
- 2023-09-14
- Lead Sponsor
- Janssen-Cilag, S.A.
- Target Recruit Count
- 41
- Registration Number
- NCT04476446
- Locations
- 🇲🇽
Ángel Alberto Ruiz Chow, Mexico, Mexico
🇲🇽Clínica de Ansiedad, Depresión y Estrés CADE, S. de R.L. de C.V., Guadalajara, Mexico
🇲🇽Hospital Espanol, Ciudad de Mexico, Mexico
Ketamine Analgesia in Third Molar Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-07-07
- Last Posted Date
- 2022-10-12
- Lead Sponsor
- Dalarna County Council, Sweden
- Target Recruit Count
- 168
- Registration Number
- NCT04459377
- Locations
- 🇸🇪
Käkkirurgiska kliniken, Falu lasarett, Falun, Dalarna, Sweden
Esketamine and Perioperative Depressive Symptoms
- Conditions
- Interventions
- First Posted Date
- 2020-06-11
- Last Posted Date
- 2023-03-22
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 564
- Registration Number
- NCT04425473
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Low-dose S-ketamine in Women With Prenatal Depression
- Conditions
- Interventions
- First Posted Date
- 2020-06-04
- Last Posted Date
- 2023-04-04
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 364
- Registration Number
- NCT04414943
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Beijing, Beijing, China
🇨🇳Peking University First Hospital, Beijing, Beijing, China
🇨🇳Huaian Maternal and Child Health Care Hospital, Huaian, Jiangsu, China
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)
- Conditions
- Interventions
- First Posted Date
- 2020-05-22
- Last Posted Date
- 2020-07-22
- Lead Sponsor
- Yan Qiu
- Target Recruit Count
- 150
- Registration Number
- NCT04399070
- Locations
- 🇨🇳
West China Hospital of Sichuan University, Department of Anesthesiology, Chengdu, Sichuan, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.