Aminophylline
- Generic Name
- Aminophylline
- Drug Type
- Small Molecule
- Chemical Formula
- C16H24N10O4
- CAS Number
- 317-34-0
- Unique Ingredient Identifier
- 27Y3KJK423
- Background
Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
- Indication
For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
- Associated Conditions
- Acute Exacerbation of Chronic Bronchitis (AECB), Asthma, Bronchial Asthma, Bronchospasm, Chronic Bronchitis, Exacerbation of asthma
Aminophylline and Cognitive Function After Sevoflurane Anaesthesia
- Conditions
- Anaesthesia
- Interventions
- First Posted Date
- 2009-12-01
- Last Posted Date
- 2010-11-19
- Lead Sponsor
- King Faisal University
- Target Recruit Count
- 180
- Registration Number
- NCT01022151
- Locations
- 🇸🇦
King Faisal University, Khobar, Eastern, Saudi Arabia
Study of MK-0476 in Adult Patients With Acute Asthma (0476-334)
- First Posted Date
- 2007-03-01
- Last Posted Date
- 2022-02-02
- Lead Sponsor
- Organon and Co
- Target Recruit Count
- 91
- Registration Number
- NCT00442338
Aminophylline in Bradyasystolic Cardiac Arrest
- Conditions
- Cardiac Arrest
- First Posted Date
- 2006-04-07
- Last Posted Date
- 2006-07-27
- Lead Sponsor
- Vancouver General Hospital
- Target Recruit Count
- 966
- Registration Number
- NCT00312273
- Locations
- 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada
Drug Development Updates
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