Cabozantinib
- Generic Name
- Cabozantinib
- Brand Names
- Cabometyx, Cometriq
- Drug Type
- Small Molecule
- Chemical Formula
- C28H24FN3O5
- CAS Number
- 849217-68-1
- Unique Ingredient Identifier
- 1C39JW444G
- Background
Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and this same formu...
- Indication
⑴治疗进展的、不能切除的局部晚期或转移的髓性甲状腺癌。
⑵用于舒尼替尼（索坦）治疗失败的晚期肾癌。
- Associated Conditions
- Advanced Renal Cell Carcinoma, Hepatocellular Carcinoma, Metastatic Differentiated Thyroid Cancer, Locally advanced Differentiated Thyroid Cancer (DTC), Metastatic Clear Cell Renal Cell Carcinoma (ccRCC), Progressive, metastatic Medullary thyroid cancer
- Associated Therapies
- -
Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer
- First Posted Date
- 2008-06-25
- Last Posted Date
- 2021-04-20
- Lead Sponsor
- Exelixis
- Target Recruit Count
- 330
- Registration Number
- NCT00704730
- Locations
- 🇺🇸
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States
🇺🇸Ohio State University, James Cancer Hospital, Columbus, Ohio, United States
🇺🇸Massachusetts General Hospital, Boston, Massachusetts, United States
Study of XL184 (Cabozantinib) in Adults With Glioblastoma Multiforme
- First Posted Date
- 2008-06-24
- Last Posted Date
- 2024-02-05
- Lead Sponsor
- Exelixis
- Target Recruit Count
- 222
- Registration Number
- NCT00704288
- Locations
- 🇺🇸
University of California, Los Angeles, Los Angeles, California, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
🇺🇸University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
A Study of XL184 (Cabozantinib) With or Without Erlotinib in Adults With Non-Small Cell Lung Cancer
- First Posted Date
- 2008-01-17
- Last Posted Date
- 2013-09-19
- Lead Sponsor
- Exelixis
- Target Recruit Count
- 92
- Registration Number
- NCT00596648
- Locations
- 🇺🇸
University of Chicago Medical Center, Chicago, Illinois, United States
🇺🇸Georgetown University/Lombardi Comprehensive Cancer Center, Washington, District of Columbia, United States
🇺🇸Park Nicollet Institute, St. Louis Park, Minnesota, United States
Study of XL184 (Cabozantinib) in Adults With Advanced Malignancies
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2013-02-27
- Lead Sponsor
- Exelixis
- Target Recruit Count
- 85
- Registration Number
- NCT00215605
- Locations
- 🇺🇸
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
🇺🇸Johns Hopkins University, Baltimore, Maryland, United States
🇺🇸Memorial Sloan Kettering Cancer Center, New York, New York, United States
Drug Development Updates
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