MedPath

Nimotuzumab

Generic Name
Nimotuzumab
Drug Type
Biotech
CAS Number
780758-10-3
Unique Ingredient Identifier
6NS400BXKH
Indication

Investigated for use/treatment in head and neck cancer, brain cancer, pediatric indications, pancreatic cancer, lung cancer, and colorectal cancer.

Associated Conditions
Advanced Head and Neck Cancer, Advanced Stage Head and Neck Cancer, Glioblastoma Multiforme (GBM), High Grade Glioma (HGG), Advanced Epithelial Tumor of the Head and Neck

Radiotherapy Plus Nimotuzumab or Cisplatin in Nasopharyngeal Carcinoma

Phase 3
Active, not recruiting
Conditions
Nasopharyngeal Carcinoma
Interventions
Drug: RT plus Cisplatin
First Posted Date
2020-07-02
Last Posted Date
2025-05-14
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
381
Registration Number
NCT04456322
Locations
🇨🇳

Sun Yat-sen Universitty Cancer Center, Guangzhou, Guangdong, China

A Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squamous Cell Carcinoma

Phase 2
Conditions
Oral Squamous Cell Carcinoma
Interventions
First Posted Date
2020-04-29
Last Posted Date
2021-11-08
Lead Sponsor
Xin-Hua Xu
Target Recruit Count
68
Registration Number
NCT04367909
Locations
🇨🇳

Department of Medical Oncology, Central Hospital of Yichang City, the First Clinical Medical College of Three Gorges University, Yichang, Hubei, China

A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer

Phase 2
Completed
Conditions
Chemoradiotherapy
Esophageal Cancer
Unresectable Malignant Neoplasm
Nimotuzumab
Interventions
Radiation: Radiotherapy
First Posted Date
2019-12-23
Last Posted Date
2024-05-16
Lead Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Target Recruit Count
55
Registration Number
NCT04207918
Locations
🇨🇳

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China

Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma

Phase 2
Conditions
Nasopharyngeal Carcinoma
Interventions
Radiation: VMAT
First Posted Date
2019-04-16
Last Posted Date
2021-01-29
Lead Sponsor
Chinese Academy of Medical Sciences
Target Recruit Count
47
Registration Number
NCT03915132
Locations
🇨🇳

Cancer hospital, Chinese Academy of Medical Sciences, Beijin, China

Radiotherapy Plus Concurrent Nimotuzumab or Cisplatin in Stage II-III Nasopharyngeal Carcinoma

Phase 3
Recruiting
Conditions
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms
Nasopharyngeal Diseases
Head and Neck Neoplasm
Interventions
First Posted Date
2019-02-12
Last Posted Date
2022-11-07
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
384
Registration Number
NCT03837808
Locations
🇨🇳

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

Study of Anti-PD-1 Antibody SHR-1210 Plus Nimotuzumab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma

Phase 2
Conditions
Esophageal Squamous Cell Carcinoma
Interventions
First Posted Date
2018-12-06
Last Posted Date
2021-07-07
Lead Sponsor
The First Affiliated Hospital of Zhengzhou University
Target Recruit Count
45
Registration Number
NCT03766178
Locations
🇨🇳

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

Nimotuzumab for Recurrent Nasopharyngeal Carcinoma

Phase 2
Conditions
Recurrent Nasopharyngeal Carcinoma
Interventions
First Posted Date
2018-09-11
Last Posted Date
2018-09-11
Lead Sponsor
Fujian Cancer Hospital
Target Recruit Count
67
Registration Number
NCT03666221
Locations
🇨🇳

Department of radiation oncology, Fujian cancer hospital, Fuzhou, Fujian, China

Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses

Phase 2
Active, not recruiting
Conditions
Diffuse Intrinsic Pontine Glioma
Interventions
First Posted Date
2018-08-08
Last Posted Date
2023-12-06
Lead Sponsor
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Target Recruit Count
54
Registration Number
NCT03620032
Locations
🇮🇹

Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Phase II Umbrella Study Directed by Next Generation Sequencing

First Posted Date
2018-07-02
Last Posted Date
2022-12-06
Lead Sponsor
Guangdong Association of Clinical Trials
Target Recruit Count
400
Registration Number
NCT03574402
Locations
🇨🇳

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China

By Comparing TPF Induction Chemotherapy Combined With Nimotuzumab Concurrent Radiotherapy and Cisplatin Concurrent Radio-chemotherapy for Locally Advanced NPC

Phase 2
Conditions
Nasopharyngeal Carcinoma
Interventions
First Posted Date
2018-06-14
Last Posted Date
2018-11-02
Lead Sponsor
Guiyang Medical University
Target Recruit Count
180
Registration Number
NCT03557112
Locations
🇨🇳

Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China

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