Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year, it was also granted approval by EMA and Health Canada, respectively. It is used in the treatment of Merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
Avelumab is indicated for the treatment of adults with metastatic Merkel cell carcinoma (MCC). In the US, it is also used in patients 12 years and older.
It is also indicated as the maintenance treatment in patients with locally advanced or metastatic urothelial carcinoma (UC), which has not progressed with first-line platinum-containing chemotherapy. In the US, avelumab is also indicated to treat locally advanced or metastatic UC with disease progression during or after platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy.
Avelumab is indicated, in combination with axitinib, for the first-line treatment of advanced renal cell carcinoma (RCC).
University of Rochester Medical Center, Rochester, New York, United States
Hospital Universitari Vall d'Hebron, Barcelona, Spain
GZA Ziekenhuizen campus Sint-Augustinus, Wilrijk, Antwerpen, Belgium
Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
M D Anderson Cancer Center, Houston, Texas, United States
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Charité Universitätsmedizin Berlin, Berlin, Germany
University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, United States
MedStar Georgetown University Hospital, Washington, District of Columbia, United States
Mount Carmel East Hospital, Columbus, Ohio, United States
Oncology Hematology Association, Pittsburgh, Pennsylvania, United States
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania, United States
Istituto Oncologico Veneto IRCCS, Padova, Italy
Sarcoma Oncology Research Center, Santa Monica, California, United States
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