Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.
- First Posted Date
- 2014-02-05
- Last Posted Date
- 2021-05-21
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 78
- Registration Number
- NCT02056288
- Locations
- 🇺🇸
Texas Children't Hospital, Houston, Texas, United States
Analgesia for Positioning Hip Fracture Patients for Spinal Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2014-01-16
- Last Posted Date
- 2014-01-16
- Lead Sponsor
- Asklepieion Voulas General Hospital
- Target Recruit Count
- 41
- Registration Number
- NCT02037633
- Locations
- 🇬🇷
Asklepieion Hospital of Voula, Athens, Attica, Greece
Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-01-16
- Last Posted Date
- 2014-10-06
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT02037802
- Locations
- 🇪🇬
Faculty of medicine, Cairo University, Cairo, Egypt
Hemodynamic Effects of Low Dose Spinal Anesthesia for Cesarean Section
- First Posted Date
- 2014-01-15
- Last Posted Date
- 2016-11-08
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 30
- Registration Number
- NCT02036697
- Locations
- 🇨🇦
Health Sciences Centre, Winnipeg, Manitoba, Canada
Remifentanil vs Fentanyl During Cardiac Surgery and Chronic Thoracic Pain
- Conditions
- Interventions
- First Posted Date
- 2014-01-09
- Last Posted Date
- 2016-10-18
- Lead Sponsor
- St. Antonius Hospital
- Target Recruit Count
- 126
- Registration Number
- NCT02031016
- Locations
- 🇳🇱
St. Antonius Hospital, Nieuwegein, Netherlands
Single Dose Morphine and Fentanyl Added to Intrathecal Mixture on Orthopedics Patients With Undiagnosed Obstructive Sleep Apnea
- First Posted Date
- 2013-12-18
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- University of Malaya
- Target Recruit Count
- 40
- Registration Number
- NCT02014714
- Locations
- 🇲🇾
University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Trial of Onset of Epidural Pain Relief With Low Dose Bupivacaine and Different Doses of Fentanyl in Laboring Women
- Conditions
- Interventions
- First Posted Date
- 2013-12-09
- Last Posted Date
- 2016-05-12
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 105
- Registration Number
- NCT02004899
- Locations
- 🇨🇦
Victoria Hospital, London, Ontario, Canada
Prothrombotic Factors and Anaesthesia in Prostate Cancer
- Conditions
- Interventions
- First Posted Date
- 2013-12-02
- Last Posted Date
- 2014-11-06
- Lead Sponsor
- Regina Elena Cancer Institute
- Target Recruit Count
- 200
- Registration Number
- NCT01998685
- Locations
- 🇮🇹
Department of Anaesthesiology, Regina Elena, National Cancer Institute, Roma, Italy
Impact of Epidural Morphine on Shoulder Pain Following Thoracotomy.
- Conditions
- Interventions
- First Posted Date
- 2013-11-14
- Last Posted Date
- 2014-05-12
- Target Recruit Count
- 22
- Registration Number
- NCT01984463
- Locations
- 🇨🇦
Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada
First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers
- First Posted Date
- 2013-11-05
- Last Posted Date
- 2019-10-24
- Lead Sponsor
- University Hospital, Rouen
- Target Recruit Count
- 35
- Registration Number
- NCT01975753
- Locations
- 🇫🇷
University Hospital, Rouen, Haute Normandie, France
Drug Development Updates
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