Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Open-Label Study to Evaluate the Effect of Treatment With Fentanyl Buccal Tablets on Pain Anxiety Symptoms When Used for the Management of Breakthrough Pain
- Conditions
- PainChronic PainBreakthrough Pain
- Interventions
- First Posted Date
- 2006-10-12
- Last Posted Date
- 2012-10-22
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 218
- Registration Number
- NCT00387010
- Locations
- 🇺🇸
Lovelace Scientific Resources, Inc., Sarasota, Florida, United States
🇺🇸Innovative Research of West Florida, Largo, Florida, United States
🇺🇸Stedman Clinical Trials, Tampa, Florida, United States
The Efficacy of Midazolam & Ketamine Versus Midazolam & Fentanyl for Sedation in Ambulatory Colonoscopies
- Conditions
- ColonoscopyConscious Sedation
- Interventions
- First Posted Date
- 2006-09-15
- Last Posted Date
- 2007-08-10
- Lead Sponsor
- Soroka University Medical Center
- Target Recruit Count
- 91
- Registration Number
- NCT00376831
- Locations
- 🇮🇱
Soroka Medical Center, Beer Sheva, Israel
Oxycodone vs Fentanyl for Pain Treatment After Laparoscopic Cholecystectomy
- Conditions
- Pain
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2007-11-19
- Lead Sponsor
- Danish Pain Research Center
- Target Recruit Count
- 80
- Registration Number
- NCT00369811
- Locations
- 🇩🇰
Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark
Efficacy and Safety of Intranasal Fentanyl in the Treatment of Breakthrough Pain (FT-018-IM)
- Conditions
- Cancer
- First Posted Date
- 2006-08-10
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 100
- Registration Number
- NCT00362583
- Locations
- 🇩🇰
Nycomed, Roskilde, Denmark
Intranasal Fentanyl for the Treatment of Breakthrough Pain in Cancer Patients (FT-017-IM)
- Conditions
- CancerPain
- First Posted Date
- 2006-06-28
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 150
- Registration Number
- NCT00345735
- Locations
- 🇩🇰
Nycomed, Roskilde, Denmark
Effect of Dexmedetomidine Upon Sleep Postoperatively
- Conditions
- Sleep
- First Posted Date
- 2006-06-06
- Last Posted Date
- 2014-07-14
- Lead Sponsor
- Duke University
- Registration Number
- NCT00333632
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer
- Conditions
- Fallopian Tube CancerPainCervical CancerEndometrial CancerOvarian CancerPerioperative/Postoperative ComplicationsSarcoma
- Interventions
- First Posted Date
- 2006-02-24
- Last Posted Date
- 2014-05-20
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 240
- Registration Number
- NCT00295945
- Locations
- 🇺🇸
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in Neonates
- First Posted Date
- 2006-02-03
- Last Posted Date
- 2009-09-16
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 32
- Registration Number
- NCT00286143
- Locations
- 🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
IVPCA in the Management of Pain Following Major Intracranial Surgery
- First Posted Date
- 2006-02-03
- Last Posted Date
- 2017-09-26
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 159
- Registration Number
- NCT00286221
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Efficacy and Safety of FITpatch Compared to Standard Opioid Treatment in Cancer Pain (FT-015-IN)
- Conditions
- Standard Opioid Analgesic Treatment of Cancer-related Chronic Pain.
- First Posted Date
- 2006-01-19
- Last Posted Date
- 2012-05-07
- Lead Sponsor
- Nycomed
- Target Recruit Count
- 220
- Registration Number
- NCT00279344
Drug Development Updates
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