Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock
- Conditions
- Septic ShockSevere SepsisInfections
- Interventions
- First Posted Date
- 2005-09-07
- Last Posted Date
- 2010-07-22
- Lead Sponsor
- University of Versailles
- Target Recruit Count
- 330
- Registration Number
- NCT00148278
- Locations
- 🇫🇷
Réanimation Polyvalente - Hôpital Nord, Marseille, France
🇫🇷Service de Réanimation Médicale - Hôpital Central, Nancy, France
🇫🇷Réanimation Médicale - Hôpital André Mignot, Le Chesnay, France
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