Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine

Phase 3

Recruiting

Conditions: Stroke, Acute
Stroke, Ischemic

Interventions: Drug: Peripheral intravenous norepinephrine

First Posted Date: 2023-09-28

Last Posted Date: 2025-01-09

Lead Sponsor: University Hospital, Bordeaux

Target Recruit Count: 358

Registration Number: NCT06059144

Locations: 🇫🇷
CHU de Bordeaux, Bordeaux, France

Vasopressor Outcomes in Spine Surgery

Early Phase 1

Recruiting

Conditions: Hypotension

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2023-09-25

Last Posted Date: 2025-01-03

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 120

Registration Number: NCT06053398

Locations: 🇺🇸
Clements University Hospital at Dallas, Dallas, Texas, United States

Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery

Phase 4

Not yet recruiting

Conditions: Hypotension During Surgery
Hypotension Drug-Induced

Interventions: Device: Hypotension Prediction Index
Drug: Norepinephrine

First Posted Date: 2023-08-01

Last Posted Date: 2023-08-03

Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Target Recruit Count: 150

Registration Number: NCT05970770

Early Initiated Vasopressor Therapy in the Emergency Department

Phase 3

Recruiting

Conditions: Shock
Hypovolemic Shock
Hypovolemic
Shock, Septic
Hypovolemia
Hypotension
Hypotension and Shock
Hypotension Symptomatic

Interventions: Drug: Noradrenaline

First Posted Date: 2023-07-05

Last Posted Date: 2024-06-10

Lead Sponsor: Odense University Hospital

Target Recruit Count: 320

Registration Number: NCT05931601

Locations: 🇩🇰
Gødstrup Regional Hospital, Herning, Denmark
🇩🇰
Esbjerg Hospital, Esbjerg, Denmark
🇩🇰
Bispebjerg Hospital, Copenhagen, Denmark

and more 2 locations

The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients

Phase 4

Recruiting

Conditions: Septic Shock

Interventions: Drug: norepinephrine+vasopressin
Drug: Norepinephrine

First Posted Date: 2023-06-02

Last Posted Date: 2023-06-02

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 60

Registration Number: NCT05886192

Locations: 🇨🇳
Peking Union Medical College Hospital, Beijing, Beijing, China

Effect of Preemptive Low Dose Norepinephrine Infusion on Intraoperative Hemodynamic Stability and Postoperative Outcomes in Patients Undergoing Brain Tumor Resection With a Craniotomy

Not Applicable

Not yet recruiting

Conditions: Brain Tumor

Interventions: Drug: norepinephrine

First Posted Date: 2023-04-18

Last Posted Date: 2023-04-18

Lead Sponsor: Yonsei University

Target Recruit Count: 70

Registration Number: NCT05814601

Locations: 🇰🇷
Yonsei University College of Medicine, Seoul, Korea, Republic of

Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty

Not Applicable

Completed

Conditions: Norepinephrine, Glypressin, Tourniquet Deflation
Hypotension

Interventions: Drug: glypressin
Drug: Saline
Drug: Norepinephrine

First Posted Date: 2023-03-17

Last Posted Date: 2023-11-22

Lead Sponsor: Tanta University

Target Recruit Count: 135

Registration Number: NCT05774067

Locations: 🇪🇬
Faculty of medicine, Tanta university, Tanta, El Gharbyia, Egypt

The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension

Not Applicable

Completed

Conditions: Sepsis
Norepinephrine
Hypotension

Interventions: Drug: Crystalloid
Drug: noradrenaline

First Posted Date: 2023-03-17

Last Posted Date: 2023-03-24

Lead Sponsor: Tanta University

Target Recruit Count: 64

Registration Number: NCT05774054

Locations: 🇪🇬
Faculty of medicine, Tanta university, Tanta, El Gharbyia, Egypt

Comparison of Hemodynamic Results of Two Different Fluid Managements

Not Applicable

Recruiting

Conditions: Perioperative Fluid Management

Interventions: Drug: isotonic solution
Drug: Noradrenaline

First Posted Date: 2023-02-17

Last Posted Date: 2023-10-23

Lead Sponsor: Istanbul University

Target Recruit Count: 40

Registration Number: NCT05733403

Locations: 🇹🇷
Istanbul University, Department of Anesthesiology, Istanbul, Fatih, Turkey

Effects of Vasopressors on Cerebral Hemodynamics in Patients with Carotid Endarterectomy (TCD Part)

Not Applicable

Completed

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-12-27

Last Posted Date: 2024-11-05

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 90

Registration Number: NCT05665881

Locations: 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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