MedPath

Danavorexton

Generic Name
Danavorexton
Drug Type
Small Molecule
Chemical Formula
C21H32N2O5S
CAS Number
2114324-48-8
Unique Ingredient Identifier
1QMD83K4YN

A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal Surgery

Phase 2
Terminated
Conditions
Sleep Apnea
Interventions
Drug: Placebo
First Posted Date
2023-04-14
Last Posted Date
2025-02-10
Lead Sponsor
Takeda
Target Recruit Count
41
Registration Number
NCT05814016
Locations
πŸ‡ΊπŸ‡Έ

Helen Keller Hospital, Sheffield, Alabama, United States

πŸ‡ΊπŸ‡Έ

Mayo Clinic - PPDS - Hospital, Phoenix, Arizona, United States

πŸ‡ΊπŸ‡Έ

UCSD, La Jolla, California, United States

and more 16 locations

A Study of Danavorexton (TAK-925) in Adults With Obstructive Sleep Apnea

Phase 1
Completed
Conditions
Sleep Apnea
Interventions
Drug: Placebo
First Posted Date
2022-01-06
Last Posted Date
2022-12-02
Lead Sponsor
Takeda
Target Recruit Count
13
Registration Number
NCT05180890
Locations
πŸ‡¦πŸ‡Ί

Adelaide Institute for Sleep Health (AISH), Flinders University, Adelaide, Australia

A Study of Danavorexton in Anesthetized Adults

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
First Posted Date
2021-08-27
Last Posted Date
2022-05-10
Lead Sponsor
Takeda
Target Recruit Count
28
Registration Number
NCT05025397
Locations
πŸ‡ΊπŸ‡Έ

Endeavor Clinical Trials, San Antonio, Texas, United States

A Study of a Single Intravenous Infusion Dose of TAK-925 in Participants With Idiopathic Hypersomnia

Phase 1
Completed
Conditions
Idiopathic Hypersomnia
Interventions
Drug: TAK-925 Placebo
First Posted Date
2019-09-16
Last Posted Date
2023-09-26
Lead Sponsor
Millennium Pharmaceuticals, Inc.
Target Recruit Count
28
Registration Number
NCT04091438
Locations
πŸ‡ΊπŸ‡Έ

Preferred Research Partners, Inc., Little Rock, Arkansas, United States

πŸ‡―πŸ‡΅

SOUSEIKAI PS Clinic, Hakata-ku, Fukuoka-Ken, Japan

πŸ‡ΊπŸ‡Έ

Pulmonary Associates Clinical Trials, Glendale, Arizona, United States

and more 19 locations

Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)

Phase 1
Completed
Conditions
Obstructive Sleep Apnea
Interventions
Drug: Placebo
First Posted Date
2019-09-16
Last Posted Date
2020-04-20
Lead Sponsor
Millennium Pharmaceuticals, Inc.
Target Recruit Count
25
Registration Number
NCT04091425
Locations
πŸ‡ΊπŸ‡Έ

Pulmonary Associates Clinical Trials, Glendale, Arizona, United States

πŸ‡ΊπŸ‡Έ

Wright Clinical Research, Alabaster, Alabama, United States

πŸ‡ΊπŸ‡Έ

Preferred Research Partners, Inc., Little Rock, Arkansas, United States

and more 15 locations

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Participants With Narcolepsy

Phase 1
Completed
Conditions
Healthy Participants
Narcolepsy
Interventions
Drug: Placebo
First Posted Date
2018-11-21
Last Posted Date
2020-12-08
Lead Sponsor
Takeda
Target Recruit Count
57
Registration Number
NCT03748979
Locations
πŸ‡―πŸ‡΅

PS Clinic, Fukuoka, Japan

πŸ‡―πŸ‡΅

Sumida Hospital, Sumida-ku, Tokyo, Japan

πŸ‡―πŸ‡΅

Hakata Clinic, Fukuoka, Japan

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
First Posted Date
2018-05-11
Last Posted Date
2021-03-26
Lead Sponsor
Takeda
Target Recruit Count
20
Registration Number
NCT03522506
Locations
πŸ‡ΊπŸ‡Έ

PRA Health Sciences, Salt Lake City, Utah, United States

Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Participants With Narcolepsy

Phase 1
Completed
Conditions
Healthy Participants and Patients With Narcolepsy
Interventions
Drug: Placebo
First Posted Date
2017-11-06
Last Posted Date
2021-03-30
Lead Sponsor
Takeda
Target Recruit Count
58
Registration Number
NCT03332784
Locations
πŸ‡―πŸ‡΅

PS Clinic, Fukuoka, Japan

πŸ‡―πŸ‡΅

Hakata Clinic, Fukuoka, Japan

πŸ‡―πŸ‡΅

Sumida Hospital, Sumida-ku, Tokyo, Japan

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