Spironolactone
- Generic Name
- Spironolactone
- Brand Names
- Aldactazide, Aldactone, Carospir, Qaialdo
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4S
- CAS Number
- 52-01-7
- Unique Ingredient Identifier
- 27O7W4T232
- Background
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat several ...
- Indication
Spironolactone is indicated for the treatment of the following conditions:
As spironolactone has antiandrogenic activity, its off-label uses include the treatment of hirsutism, female pattern hair loss, and adult acne vulgaris.
- Associated Conditions
- Edema, Hypertension, Primary Aldosteronism, Primary Hyperaldosteronism, Secondary hyperaldosteronism, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV), Idiopathic hyperaldosteronism, Refractory Edema
- Associated Therapies
- Perioperative drug treatment, Maintenance therapy
Spironolactone Safety in African Americans with Mild Cognitive Impairment and Early Dementia
- Conditions
- Interventions
- First Posted Date
- 2020-08-21
- Last Posted Date
- 2024-10-15
- Lead Sponsor
- Emory University
- Target Recruit Count
- 30
- Registration Number
- NCT04522739
- Locations
- 🇺🇸
Emory Clinic at Executive Park, Atlanta, Georgia, United States
Antiarrhythmic Effects of Spironolactone in Patients With ICDs
- First Posted Date
- 2020-08-03
- Last Posted Date
- 2020-10-09
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 90
- Registration Number
- NCT04495712
- Locations
- 🇺🇸
VA Portland Health Care System, Portland, OR, Portland, Oregon, United States
The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure
- First Posted Date
- 2020-07-02
- Last Posted Date
- 2021-12-08
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 200
- Registration Number
- NCT04455178
- Locations
- 🇨🇳
Kunshan First Renmin Hospital, Kunshan, Jiangsu, China
🇨🇳Changzhi Heping Hospital, Changzhi, Shanxi, China
🇨🇳Dongtai Renmin Hospital, Dongtai, Jiangsu, China
The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.
- Conditions
- Interventions
- First Posted Date
- 2020-05-19
- Last Posted Date
- 2020-09-14
- Lead Sponsor
- Hospital Civil de Guadalajara
- Target Recruit Count
- 80
- Registration Number
- NCT04393493
- Locations
- 🇲🇽
HCG, Guadalajara, Jalisco, Mexico
🇲🇽Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico
Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension
- First Posted Date
- 2020-04-02
- Last Posted Date
- 2024-08-26
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 118
- Registration Number
- NCT04331691
- Locations
- 🇰🇷
Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea, Republic of
Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients
- First Posted Date
- 2019-12-19
- Last Posted Date
- 2022-04-19
- Lead Sponsor
- University of Michigan
- Registration Number
- NCT04205136
- Locations
- 🇺🇸
The University of Michigan, Ann Arbor, Michigan, United States
Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial
- Conditions
- Interventions
- First Posted Date
- 2019-12-09
- Last Posted Date
- 2023-05-24
- Lead Sponsor
- Mayo Clinic
- Registration Number
- NCT04190433
Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
- Conditions
- Interventions
- First Posted Date
- 2019-08-30
- Last Posted Date
- 2023-10-27
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 24
- Registration Number
- NCT04075149
- Locations
- 🇺🇸
University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States
A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure
- First Posted Date
- 2019-06-13
- Last Posted Date
- 2023-02-01
- Lead Sponsor
- Bispebjerg Hospital
- Target Recruit Count
- 7200
- Registration Number
- NCT03984591
- Locations
- 🇩🇰
Bispebjerg Hospital, Copenhagen, Denmark
Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients
- Conditions
- Interventions
- First Posted Date
- 2019-05-17
- Last Posted Date
- 2019-09-04
- Lead Sponsor
- Chiang Mai University
- Target Recruit Count
- 84
- Registration Number
- NCT03953950
- Locations
- 🇹🇭
Pharmacoepidemiology and Statistics Research Center, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand
Drug Development Updates
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