Spironolactone
- Generic Name
- Spironolactone
- Brand Names
- Aldactazide, Aldactone, Carospir, Qaialdo
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4S
- CAS Number
- 52-01-7
- Unique Ingredient Identifier
- 27O7W4T232
- Background
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat several ...
- Indication
Spironolactone is indicated for the treatment of the following conditions:
As spironolactone has antiandrogenic activity, its off-label uses include the treatment of hirsutism, female pattern hair loss, and adult acne vulgaris.
- Associated Conditions
- Edema, Hypertension, Primary Aldosteronism, Primary Hyperaldosteronism, Secondary hyperaldosteronism, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV), Idiopathic hyperaldosteronism, Refractory Edema
- Associated Therapies
- Perioperative drug treatment, Maintenance therapy
The Effect of SAAE on Vascular Endothelial Function in PA Patients
- Conditions
- Interventions
- First Posted Date
- 2022-09-30
- Last Posted Date
- 2024-04-17
- Target Recruit Count
- 200
- Registration Number
- NCT05561361
- Locations
- 🇨🇳
The Second Affiliated Hospital of Nanchang University, Nanchang, China
The Effect of SAAE on Ventricular Remodeling in PA Patients
- Conditions
- Interventions
- First Posted Date
- 2022-08-15
- Last Posted Date
- 2024-04-17
- Target Recruit Count
- 112
- Registration Number
- NCT05501080
- Locations
- 🇨🇳
The Second Affiliated Hospital of Nanchang University, Nanchang, China
A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)
- Conditions
- Interventions
- First Posted Date
- 2022-05-27
- Last Posted Date
- 2024-04-22
- Lead Sponsor
- Fundació Sant Joan de Déu
- Target Recruit Count
- 364
- Registration Number
- NCT05394142
- Locations
- 🇮🇹
Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy
🇪🇸Hospital Sant Joan de Deu, Esplugues De Llobregat, Spain
🇪🇸Hospital Universitari de Girona Dr. Trueta, Girona, Spain
Spironolactone in CKD Enabled by Chlorthalidone: PILOT
- Conditions
- Interventions
- First Posted Date
- 2022-02-03
- Last Posted Date
- 2023-08-14
- Lead Sponsor
- Indiana Institute for Medical Research
- Target Recruit Count
- 24
- Registration Number
- NCT05222191
- Locations
- 🇺🇸
Richard L Roudebush VA Medical Center, Indianapolis, Indiana, United States
Evaluation of Spironolactone Efficacy in Patient With Rheumatoid Arthritis (RA)
- First Posted Date
- 2021-10-26
- Last Posted Date
- 2022-12-07
- Lead Sponsor
- University Hospital, Strasbourg, France
- Target Recruit Count
- 154
- Registration Number
- NCT05092984
- Locations
- 🇫🇷
University Hospital, Strasbourg, France, Strasbourg, Alsace, France
Transgender Estradiol Affirming Therapy
- First Posted Date
- 2021-08-18
- Last Posted Date
- 2024-11-26
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 39
- Registration Number
- NCT05010707
- Locations
- 🇺🇸
Washington University Transgender Center, Saint Louis, Missouri, United States
Fibrosis and the Fontan
- First Posted Date
- 2021-05-26
- Last Posted Date
- 2024-05-10
- Lead Sponsor
- Children's Hospital of Philadelphia
- Target Recruit Count
- 120
- Registration Number
- NCT04901975
- Locations
- 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
- Conditions
- Interventions
- First Posted Date
- 2021-01-26
- Last Posted Date
- 2023-10-27
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 32
- Registration Number
- NCT04723862
- Locations
- 🇺🇸
Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia, United States
Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure
- Conditions
- Interventions
- First Posted Date
- 2020-11-06
- Last Posted Date
- 2020-11-10
- Lead Sponsor
- Laikο General Hospital, Athens
- Target Recruit Count
- 50
- Registration Number
- NCT04618601
- Locations
- 🇬🇷
Laiko General Hospital, Athens, Attiki, Greece
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
- First Posted Date
- 2020-10-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 400
- Registration Number
- NCT04582383
- Locations
- 🇺🇸
Johnson Dermatology, Fort Smith, Arkansas, United States
🇺🇸North Texas Center for Clinical Research, Frisco, Texas, United States
🇺🇸Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Drug Development Updates
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