Calcitriol

Generic Name: Calcitriol

Brand Names: Rocaltrol, Vectical

Drug Type: Small Molecule

Chemical Formula: C_₂₇H_₄₄O_₃

CAS Number: 32222-06-3

Unique Ingredient Identifier: FXC9231JVH

Background: Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to Vitamin D3 (vita...

Indication: Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or...

Associated Conditions: Hypocalcemia, Mild to Moderate Plaque Psoriasis, Osteodystrophy, Secondary Hyperparathyroidism (SHPT), Vitamin D Resistant Rickets

Associated Therapies: -

Clinical Trials

Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy

Phase 4

Completed

Conditions: IGA Nephropathy

First Posted Date: 2006-04-27

Last Posted Date: 2009-01-30

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 10

Registration Number: NCT00319761

Locations: 🇭🇰
Department of Medicine & Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong

DN-101 in Combination With Docetaxel in Androgen-Independent Prostate Cancer (AIPC) (AIPC Study of Calcitriol Enhancing Taxotere [ASCENT-2])

Phase 3

Terminated

Conditions: Prostate Cancer

First Posted Date: 2006-01-09

Last Posted Date: 2007-11-06

Lead Sponsor: Novacea

Target Recruit Count: 1200

Registration Number: NCT00273338

Locations: 🇺🇸
UCLA department of Urology, Los Angeles, California, United States
🇺🇸
Hematology Oncology Associates of Illinois, Chicago, Illinois, United States
🇺🇸
The Cleveland Clinic Foundation, Cleveland, Ohio, United States

and more 209 locations

Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium

Phase 4

Completed

Conditions: Secondary Hyperparathyroidism
Chronic Kidney Disease

First Posted Date: 2003-12-04

Last Posted Date: 2006-08-02

Lead Sponsor: Abbott

Target Recruit Count: 30

Registration Number: NCT00073710

Locations: 🇺🇸
Creighton University, Omaha, Nebraska, United States

Evaluate the Survival Benefits of Zemplar Versus Calcijex in Subjects w/ Stage V Chronic Kidney Disease on Hemodialysis

Phase 4

Terminated

Conditions: End-Stage Kidney Disease

First Posted Date: 2003-06-13

Last Posted Date: 2006-08-02

Lead Sponsor: Abbott

Target Recruit Count: 2200

Registration Number: NCT00062699

Locations: 🇺🇸
Gambro Healthcare - Los Angeles, Los Angeles, California, United States
🇺🇸
Paul Light, University of Maryland, Baltimore, Maryland, United States
🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

and more 56 locations

ASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere

Phase 2

Conditions: Prostate Cancer

First Posted Date: 2002-08-13

Last Posted Date: 2009-03-12

Lead Sponsor: Novacea

Target Recruit Count: 250

Registration Number: NCT00043576

Locations: 🇺🇸
Tower Hematology Oncology Medical Group, Los Angeles, California, United States
🇺🇸
Texas Oncology, P.A., Dallas, Texas, United States
🇺🇸
Kaiser- Northern California, Vallejo, California, United States

and more 59 locations

Calcitriol and Dexamethasone in Patients With Myelodysplastic Syndromes

Phase 2

Completed

Conditions: Myelodysplastic Syndromes

First Posted Date: 2002-01-31

Last Posted Date: 2016-01-15

Lead Sponsor: University of Pittsburgh

Target Recruit Count: 32

Registration Number: NCT00030069

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Study of Topical Calcitriol in Children With Psoriasis

Not Applicable

Completed

Conditions: Psoriasis

First Posted Date: 2000-09-12

Last Posted Date: 2005-06-24

Lead Sponsor: National Center for Research Resources (NCRR)

Target Recruit Count: 20

Registration Number: NCT00006275

Osteoporosis Prevention After Heart Transplant

Phase 3

Completed

Conditions: Cardiac Transplantation
Osteoporosis

Interventions: Drug: Alendronate
Drug: Calcitriol
Drug: Placebo Alendronate
Drug: Placebo Calcitriol

First Posted Date: 1999-11-04

Last Posted Date: 2015-07-07

Lead Sponsor: Columbia University

Target Recruit Count: 149

Registration Number: NCT00000412

Locations: 🇺🇸
Columbia University Medical Center, New York, New York, United States
🇺🇸
Columbai University Medical Center, New York, New York, United States

Studies With 1,25-Dihydroxycholecalciferol

Phase 2

Terminated

Conditions: Hypocalcemia
Rickets

Interventions: Drug: 1,25-Dihydroxycholecalciferol

First Posted Date: 1999-11-04

Last Posted Date: 2013-11-25

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 6

Registration Number: NCT00001151

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis

Phase 2

Completed

Conditions: Renal Osteodystrophy
End Stage Renal Disease

First Posted Date: 1999-10-19

Last Posted Date: 2005-06-24

Lead Sponsor: National Center for Research Resources (NCRR)

Target Recruit Count: 109

Registration Number: NCT00004340

Locations: 🇺🇸
University of California Los Angeles School of Medicine, Los Angeles, California, United States

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