Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Magnesium and TKA Pain
- First Posted Date
- 2013-09-18
- Last Posted Date
- 2013-09-18
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT01945437
Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam
- Conditions
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2017-03-07
- Target Recruit Count
- 26
- Registration Number
- NCT01940250
- Locations
- 🇻🇳
Hospital for Tropical Diseases, Ho CHi Minh City, Vietnam
🇻🇳Children's Hospital 1, Ho Chi Minh City, Vietnam
Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-09-10
- Last Posted Date
- 2015-11-20
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 44
- Registration Number
- NCT01938300
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea, Republic of
Comparison of the Effect of Magnesium Sulfate and Dexamethasone on Postoperative Sore Throat After Spinal Surgery in Prone Position With Tracheal Intubation: a Double-blind, Randomized, Noninferiority Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2013-08-16
- Last Posted Date
- 2015-03-17
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 146
- Registration Number
- NCT01923831
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
Community Level Interventions for Pre-eclampsia
- Conditions
- Interventions
- First Posted Date
- 2013-07-30
- Last Posted Date
- 2019-06-27
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 87500
- Registration Number
- NCT01911494
- Locations
- 🇮🇳
Jawaharlal Nehru Medical College, Karnataka Lingayat Education University, Belgaum, Karnataka, India
🇵🇰Aga Khan University, Karachi, Sindh, Pakistan
🇲🇿Centro de Investigacaoem Saude de Manhica (CISM), Maputo, Mozambique
Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
- Conditions
- Interventions
- First Posted Date
- 2013-05-20
- Last Posted Date
- 2013-05-20
- Lead Sponsor
- Chongqing Medical University
- Target Recruit Count
- 330
- Registration Number
- NCT01856959
- Locations
- 🇨🇳
Center of Respiratory Disorders,Children's Hospital,Chongqing Medical University, Chongqing, Chongqing, China
New Magnesium Sulphate Protocol for Pre-eclampsia
- First Posted Date
- 2013-05-03
- Last Posted Date
- 2014-08-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 240
- Registration Number
- NCT01846156
- Locations
- 🇪🇬
Kasr Alainy hospital, Cairo, Egypt
Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-04-30
- Last Posted Date
- 2013-07-02
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 105
- Registration Number
- NCT01843296
- Locations
- 🇮🇷
Alzahra, Isfahan, Iran, Islamic Republic of
Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex
- First Posted Date
- 2013-04-10
- Last Posted Date
- 2015-01-21
- Lead Sponsor
- Universidade Federal do Rio de Janeiro
- Target Recruit Count
- 80
- Registration Number
- NCT01828385
- Locations
- 🇧🇷
Hospital Federal de Bonsucesso, Rio de Janeiro, RJ, Brazil
Magnesium Sulphate and Rocuronium in Patients Over 60
- First Posted Date
- 2013-03-05
- Last Posted Date
- 2018-03-14
- Lead Sponsor
- Pedro Rotava
- Target Recruit Count
- 64
- Registration Number
- NCT01804205
- Locations
- 🇧🇷
Instituto Nacional de Câncer, Rio de Janeiro, Brazil
Drug Development Updates
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