Remimazolam

Generic Name: Remimazolam

Brand Names: Byfavo

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₁₉BrN_₄O_₂

CAS Number: 308242-62-8

Unique Ingredient Identifier: 7V4A8U16MB

Background: Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.

Indication: Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.

Associated Conditions: Procedural Sedation

Clinical Trials

Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Not Applicable

Completed

Conditions: Drug Effect

Interventions: Drug: Esketamine
Drug: Remimazolam
Drug: Propofol
Drug: remifentanil

First Posted Date: 2023-01-17

Last Posted Date: 2023-08-21

Lead Sponsor: Tongji Hospital

Target Recruit Count: 106

Registration Number: NCT05686863

Locations: 🇨🇳
Tongji Hospital, Wuhan, Hubei, China

Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery

Phase 4

Completed

Conditions: Sedatives
Anesthesia, Spinal
Remimazolam
Propofol
Orthopedic Procedures

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2022-12-15

Last Posted Date: 2025-02-26

Lead Sponsor: Asan Medical Center

Target Recruit Count: 78

Registration Number: NCT05651399

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position

Phase 4

Completed

Conditions: Hemodynamic Instability

Interventions: Drug: Propofol
Drug: Remimazolam

First Posted Date: 2022-12-09

Last Posted Date: 2025-02-26

Lead Sponsor: Asan Medical Center

Target Recruit Count: 94

Registration Number: NCT05644483

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Remimazolam Versus Propofol for Painless Abortion

Phase 2

Completed

Conditions: Anesthesia
Abortion Early

Interventions: Drug: Remimazolam
Drug: Propofol
Drug: Esketamine

First Posted Date: 2022-12-02

Last Posted Date: 2022-12-02

Lead Sponsor: Maternal and Child Health Hospital of Hubei Province

Target Recruit Count: 100

Registration Number: NCT05635955

Locations: 🇨🇳
Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China

95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment

Not Applicable

Completed

Conditions: Lung Cancer
Anesthesia Induction

Interventions: Drug: Dexmedetomidine
Drug: Remimazolam tosilate

First Posted Date: 2022-11-30

Last Posted Date: 2023-03-14

Lead Sponsor: Shiyou Wei

Target Recruit Count: 115

Registration Number: NCT05631028

Locations: 🇨🇳
Shanghai Pulmonary Hospital, Shanghai, Shanghai, China

RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery

Phase 4

Recruiting

Conditions: Remimazolam Besylate
Sedation
ICU

Interventions: Drug: Remimazolam Besylate
Drug: Midazolam
Drug: Propofol

First Posted Date: 2022-11-04

Last Posted Date: 2024-01-09

Lead Sponsor: Nanfang Hospital, Southern Medical University

Target Recruit Count: 285

Registration Number: NCT05606315

Locations: 🇨🇳
Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
🇨🇳
Southern medical university Nanfang hospital, Guangzhou, Guangdong, China

Comparison of the Effect of Remimazolam and Propofol on Perioperative Hypothermia Under Spinal Anesthesia

Not Applicable

Completed

Conditions: Lower Extremity Problem
Gynecologic Disease
Urinary Tract Disease

Interventions: Drug: Propofol
Drug: Remimazolam

First Posted Date: 2022-10-10

Last Posted Date: 2022-10-10

Lead Sponsor: Wonkwang University Hospital

Target Recruit Count: 82

Registration Number: NCT05574257

Locations: 🇰🇷
Wonkwag UH, Iksan, Jeollabukdo, Korea, Republic of

Long-term Sedation With Remimazolam Besylate in Critically Ill Patients

Phase 3

Recruiting

Conditions: Light Sedation
Mechanical Ventilation

Interventions: Drug: Remimazolam besylate
Drug: Propofol

First Posted Date: 2022-09-27

Last Posted Date: 2023-05-26

Lead Sponsor: Wuhan Union Hospital, China

Target Recruit Count: 728

Registration Number: NCT05555667

Locations: 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China