DeepMed Research

Theophylline

Generic Name: Theophylline

Brand Names: Elixophyllin, Elixophylline, Pulmophylline, Quibron-T, Theo-24, Theolair, Uniphyl

Drug Type: Small Molecule

Chemical Formula: C_₇H_₈N_₄O_₂

CAS Number: 58-55-9

Unique Ingredient Identifier: 0I55128JYK

Background: A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.

Indication: For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.

Associated Conditions: Asthma, Bronchitis, Bronchoconstriction, Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD), Chronic bronchial inflammation

Associated Therapies: Airway secretion clearance therapy, Bronchodilation

Clinical Trials

Theophylline Nasal Spray for PD-Related Hyposmia and Anosmia

Phase 1

Withdrawn

Conditions: Hyposmia
Anosmia

Interventions: Drug: CYR-064

First Posted Date: 2024-07-12

Last Posted Date: 2025-03-13

Lead Sponsor: University of Nebraska

Target Recruit Count: 15

Registration Number: NCT06498687

Locations: 🇺🇸
University of Nebraska Medical Center/Nebraska Medicine, Omaha, Nebraska, United States

Effect of Tigulixostat on the Pharmacokinetics of Theophylline

Phase 1

Completed

Conditions: Hyperuricemia
Gout

Interventions: Drug: Tigulixostat
Drug: Theophylline

First Posted Date: 2024-01-03

Last Posted Date: 2024-01-03

Lead Sponsor: LG Chem

Target Recruit Count: 24

Registration Number: NCT06189404

Locations: 🇺🇸
PPD - Austin Research Unit, Austin, Texas, United States

Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3)

Phase 2

Active, not recruiting

Conditions: COVID-19

Interventions: Drug: theophylline
Drug: Placebo

First Posted Date: 2023-07-17

Last Posted Date: 2024-07-10

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 41

Registration Number: NCT05947643

Locations: 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States

Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage

Phase 1

Recruiting

Conditions: Acute Kidney Injury
HIE

Interventions: Drug: Single Dose Theophylline
Drug: Repeat Dose Theophylline

First Posted Date: 2023-05-11

Last Posted Date: 2025-03-24

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 30

Registration Number: NCT05853601

Locations: 🇺🇸
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Theophylline Effects in the Fontan Circulation

Phase 2

Completed

Conditions: Congenital Heart Disease

Interventions: Drug: Theophylline Tablets

First Posted Date: 2023-02-08

Last Posted Date: 2023-09-21

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 10

Registration Number: NCT05717049

Locations: 🇳🇴
Oslo University Hospital, Rikshospitalet, Department of Paediatric Cardiology, Oslo, Norway

Smell in Covid-19 and Efficacy of Nasal Theophylline

Phase 2

Completed

Conditions: Covid-19 Pandemic
SARS-CoV-2 Infection
Hyposmia
Covid19
Ageusia
Hypogeusia
Olfactory Disorder
Anosmia

Interventions: Drug: Theophylline Powder
Drug: Placebo Comparator

First Posted Date: 2021-03-09

Last Posted Date: 2023-05-24

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 51

Registration Number: NCT04789499

Locations: 🇺🇸
Washington University School of Medicine in Saint Louis, Saint Louis, Missouri, United States

Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old

Phase 2

Recruiting

Conditions: Pseudohypoparathyroidism Type 1a
Pseudohypoparathyroidism
Albright Hereditary Osteodystrophy

Interventions: Drug: Placebo
Drug: Theophylline

First Posted Date: 2020-09-16

Last Posted Date: 2024-11-01

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 34

Registration Number: NCT04551170

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Theophylline for Depression Study

Early Phase 1

Withdrawn

Conditions: Depression

Interventions: Drug: Theophylline ER
Other: PO placebo
Other: IV placebo
Biological: Lipopolysaccharide (LPS)

First Posted Date: 2020-03-16

Last Posted Date: 2021-11-05

Lead Sponsor: University of California, Los Angeles

Registration Number: NCT04309877

Locations: 🇺🇸
UCLA Cousins Center for Psychoneuroimmunology, Los Angeles, California, United States

Diaphragmatic Ultrasound With Theophylline Therapeutic Trials

Early Phase 1

Conditions: Diaphragmatic Dysfunction in Critically Ill Patients

Interventions: Drug: Theophylline

First Posted Date: 2020-02-13

Last Posted Date: 2020-02-13

Lead Sponsor: Assiut University

Target Recruit Count: 46

Registration Number: NCT04269187

Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural Puncture Headache

Phase 4

Completed

Conditions: Post-Dural Puncture Headache

Interventions: Drug: Theophylline Anhydrous Oral Tablet
Drug: Sumatriptan Succinate Oral Tablet

First Posted Date: 2020-02-06

Last Posted Date: 2021-06-03

Lead Sponsor: Damanhour Teaching Hospital

Target Recruit Count: 60

Registration Number: NCT04257851

Locations: 🇪🇬
Damanhour Teaching Hospital, Damanhūr, El-Beheira, Egypt

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