Theophylline
- Generic Name
- Theophylline
- Brand Names
- Elixophyllin, Elixophylline, Pulmophylline, Quibron-T, Theo-24, Theolair, Uniphyl
- Drug Type
- Small Molecule
- Chemical Formula
- C7H8N4O2
- CAS Number
- 58-55-9
- Unique Ingredient Identifier
- 0I55128JYK
- Background
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theo...
- Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
- Associated Conditions
- Asthma, Bronchitis, Bronchoconstriction, Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD), Chronic bronchial inflammation
- Associated Therapies
- Airway secretion clearance therapy, Bronchodilation
Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline
- Conditions
- Interventions
- First Posted Date
- 2013-12-05
- Last Posted Date
- 2014-08-20
- Lead Sponsor
- Zhujiang Hospital
- Target Recruit Count
- 102
- Registration Number
- NCT02001935
- Locations
- 🇨🇳
Zhujiang Hospital,Southern Medical Universtiy, Guangzhou, Guangdong, China
Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer
- First Posted Date
- 2013-02-26
- Last Posted Date
- 2014-11-17
- Lead Sponsor
- Eckhard Podack
- Registration Number
- NCT01799161
The Role of Theophylline Plus Low-dose Formoterol-budesonide in Treatment of Bronchiectasis
- Conditions
- Interventions
- First Posted Date
- 2013-01-17
- Last Posted Date
- 2015-03-11
- Target Recruit Count
- 50
- Registration Number
- NCT01769898
- Locations
- 🇨🇳
State Key Laboratory of Respiratory Research Institute., Guangzhou City, Guangdong, China
🇨🇳The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
The Effect of Theophylline in the Treatment of Bronchiectasis
- Conditions
- Interventions
- First Posted Date
- 2012-09-13
- Last Posted Date
- 2015-03-11
- Target Recruit Count
- 100
- Registration Number
- NCT01684683
- Locations
- 🇨🇳
State Key Laboratory of Respiratory Research Institute., Guangzhou City, Guangdong, China
Drug Interaction Study of Colchicine and Theophylline
- First Posted Date
- 2012-05-17
- Last Posted Date
- 2013-06-17
- Lead Sponsor
- Takeda
- Target Recruit Count
- 30
- Registration Number
- NCT01601132
- Locations
- 🇺🇸
Worlwide Clinical Trials Drug Development Solutions, Clinical Research Services, San Antonio, Texas, United States
Low-dose Theophylline as Anti-inflammatory Enhancer in Severe Chronic Obstructive Pulmonary Disease
- Conditions
- Interventions
- First Posted Date
- 2012-05-16
- Last Posted Date
- 2017-08-29
- Lead Sponsor
- Hospital Son Espases
- Target Recruit Count
- 70
- Registration Number
- NCT01599871
- Locations
- 🇪🇸
Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
🇪🇸Hospital del Mar, Barcelona, Spain
🇪🇸Hospital Clínic de Barcelona, Barcelona, Spain
A Study of LY2216684 and Theophylline in Healthy Subjects
- First Posted Date
- 2010-12-20
- Last Posted Date
- 2019-07-08
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 21
- Registration Number
- NCT01263106
- Locations
- 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Dallas, Texas, United States
CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity
- First Posted Date
- 2010-02-10
- Last Posted Date
- 2010-03-03
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 87
- Registration Number
- NCT01066728
- Locations
- 🇨🇦
Health Sciences Centre, Winnipeg, Manitoba, Canada
🇨🇦St Boniface General Hospital, Winnipeg, Manitoba, Canada
A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer
- Conditions
- Interventions
- First Posted Date
- 2009-11-23
- Last Posted Date
- 2013-04-12
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 34
- Registration Number
- NCT01017939
- Locations
- 🇺🇸
START - South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas, United States
🇺🇸Tower Cancer Research Foundation, Beverly Hills, California, United States
🇨🇦BC Cancer Agency, Vancouver, British Columbia, Canada
Drug-Drug Interaction Study of Colchicine and Theophylline
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2010-03-02
- Lead Sponsor
- Mutual Pharmaceutical Company, Inc.
- Target Recruit Count
- 30
- Registration Number
- NCT00983905
- Locations
- 🇺🇸
PRACS Institute, Ltd. - Cetero Research, Fargo, North Dakota, United States
Drug Development Updates
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