Simvastatin
- Generic Name
- Simvastatin
- Brand Names
- Cholib, FloLipid, Simcor, Vytorin, Zocor
- Drug Type
- Small Molecule
- Chemical Formula
- C25H38O5
- CAS Number
- 79902-63-9
- Unique Ingredient Identifier
- AGG2FN16EV
- Background
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...
- Indication
Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
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- Associated Conditions
- Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
- Associated Therapies
- -
Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLD
- Conditions
- Interventions
- First Posted Date
- 2017-12-18
- Last Posted Date
- 2017-12-19
- Target Recruit Count
- 196
- Registration Number
- NCT03375580
- Locations
- 🇨🇳
First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China
A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin
- First Posted Date
- 2017-06-02
- Last Posted Date
- 2019-09-24
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 63
- Registration Number
- NCT03174041
- Locations
- 🇺🇸
Covance Research Unit - Daytona, Daytona Beach, Florida, United States
🇺🇸Covance Clinical Research Unit Inc.; Covance Gfi Research, Evansville, Indiana, United States
🇺🇸Covance Clinical Research Unit, Inc, Madison, Wisconsin, United States
A Phase I Study of High Dose Simvastatin in Patients With Gastrointestinal Tract Cancer Who Failed to Standard Chemotherapy
- First Posted Date
- 2017-03-22
- Last Posted Date
- 2019-12-30
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 9
- Registration Number
- NCT03086291
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Simvastatin Metabolism as a Test for CD Activity (IRB 15-007568]
- First Posted Date
- 2017-01-06
- Last Posted Date
- 2024-08-05
- Lead Sponsor
- Entero Therapeutics
- Target Recruit Count
- 40
- Registration Number
- NCT03011931
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Evaluation Of The Portal Pressure By Doppler Ultrasound In Cirrhotic Patients Before And After Simvastatin
- First Posted Date
- 2016-12-15
- Last Posted Date
- 2018-03-08
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 40
- Registration Number
- NCT02994485
- Locations
- 🇪🇬
Sherief Abd-Elsalam, Tanta, Egypt
Simvastatin in Overcoming Chemotherapy Resistance in Patients With Relapsed or Refractory Multiple Myeloma
- Conditions
- Interventions
- First Posted Date
- 2016-11-23
- Last Posted Date
- 2018-07-02
- Lead Sponsor
- Wake Forest University Health Sciences
- Registration Number
- NCT02971410
- Locations
- 🇺🇸
Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina, United States
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
- First Posted Date
- 2016-11-21
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 59
- Registration Number
- NCT02968810
- Locations
- 🇵🇷
Centro Comprensivo de Cancer de UPR, San Juan, Puerto Rico
🇺🇸Northwestern University, Chicago, Illinois, United States
🇺🇸MedStar Georgetown University Hospital, Washington, District of Columbia, United States
Simvastatin to Prevent SCI-Induced Bone Loss
- Conditions
- Interventions
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2021-12-08
- Lead Sponsor
- Craig Hospital
- Target Recruit Count
- 76
- Registration Number
- NCT02946424
- Locations
- 🇺🇸
Craig Hospital, Englewood, Colorado, United States
Randomized Comparative Efficacy and Safety Study of Intermittent Simvastatin and Fenofibrate in Hemodialysis
- Conditions
- Interventions
- First Posted Date
- 2016-09-01
- Last Posted Date
- 2016-09-05
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT02886299
Effect of Statin Use on Aldosterone Secretion
- Conditions
- Interventions
- First Posted Date
- 2016-08-18
- Last Posted Date
- 2022-09-29
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 103
- Registration Number
- NCT02871687
- Locations
- 🇺🇸
Brigham and Women's Hospital- 221 Longwood Avenue, Boston, Massachusetts, United States
Drug Development Updates
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