Plazomicin
- Generic Name
- Plazomicin
- Brand Names
- Zemdri
- Drug Type
- Small Molecule
- Chemical Formula
- C25H48N6O10
- CAS Number
- 1154757-24-0
- Unique Ingredient Identifier
- LYO9XZ250J
- Background
Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from Sisomicin. The structure of plazomicin was established via appending hydroxylaminobutyric acid to Sisomicin at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzyme...
- Indication
Plazomicin is indicated for the treatment of patients 18 years of age or older with Complicated Urinary Tract Infections (cUTI) including Pyelonephritis, who have limited or no alternative treatment options. It should only be used to treat infections that are proven or strongly suspected to be caused by susceptible microorganisms .
- Associated Conditions
- Complicated Urinary Tract Infection, Pyelonephritis
- Associated Therapies
- -
A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin
- First Posted Date
- 2017-09-01
- Last Posted Date
- 2017-10-11
- Lead Sponsor
- Achaogen, Inc.
- Target Recruit Count
- 16
- Registration Number
- NCT03270553
- Locations
- 🇺🇸
Clinical Site, Lincoln, Nebraska, United States
A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)
- Conditions
- Interventions
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2018-08-23
- Lead Sponsor
- Achaogen, Inc.
- Target Recruit Count
- 609
- Registration Number
- NCT02486627
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
- Conditions
- Interventions
- First Posted Date
- 2013-10-28
- Last Posted Date
- 2018-10-16
- Lead Sponsor
- Achaogen, Inc.
- Target Recruit Count
- 69
- Registration Number
- NCT01970371
A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)
- Conditions
- Interventions
- First Posted Date
- 2010-03-31
- Last Posted Date
- 2018-08-22
- Lead Sponsor
- Achaogen, Inc.
- Target Recruit Count
- 145
- Registration Number
- NCT01096849
Drug Development Updates
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