Anakinra
- Generic Name
- Anakinra
- Brand Names
- Kineret
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 143090-92-0
- Unique Ingredient Identifier
- 9013DUQ28K
- Background
Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. Anakinra is indicated for the managemen...
- Indication
Anakinra is an interleukin-1 receptor antagonist indicated for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis (RA), in patients 18 years of age or older who have failed one or more disease-modifying antirheumatic drugs (DMARDs). Anakinra can be used alone or in combin...
- Associated Conditions
- Coronavirus Disease 2019 (COVID‑19), Cryopyrin-associated Periodic Syndromes (CAPS), Deficiency of the interleukin-1 receptor antagonist, Idiopathic Recurrent Pericarditis, Moderately to Severely Active Rheumatoid Arthritis, Neonatal-Onset Multisystem Inflammatory Disease (NOMID), Systemic Juvenile Idiopathic Arthritis (SJIA)
- Associated Therapies
- -
Effects of IL-1 Beta on the HPA-axis in Obese Persons
- First Posted Date
- 2014-08-28
- Last Posted Date
- 2016-08-23
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 76
- Registration Number
- NCT02227420
- Locations
- 🇨🇭
University Hopsital Basel, Basel, Switzerland
AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)
- First Posted Date
- 2014-08-19
- Last Posted Date
- 2015-12-18
- Lead Sponsor
- Massimo Imazio
- Target Recruit Count
- 21
- Registration Number
- NCT02219828
- Locations
- 🇮🇹
Cardiology Dpt, Maria Vittoria Hospital, Torino, Italy
🇮🇹Pediatric Dept. Ospedale Gaslini, Genova, Italy
🇮🇹Internal Medicine Division, OSpedale Papa Giovanni XXIII, Bergamo, Italy
Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease
- First Posted Date
- 2014-07-02
- Last Posted Date
- 2024-03-04
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 22
- Registration Number
- NCT02179853
- Locations
- 🇺🇸
Rady Children's Hospital San Diego, San Diego, California, United States
Interleukin-1 Blockade in HF With Preserved EF
- Conditions
- Interventions
- First Posted Date
- 2014-06-25
- Last Posted Date
- 2018-06-19
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 31
- Registration Number
- NCT02173548
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
Cytokine Inhibition in Chronic Fatigue Syndrome Patients
- First Posted Date
- 2014-04-09
- Last Posted Date
- 2016-05-25
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT02108210
- Locations
- 🇳🇱
RadboudUMC, Nijmegen, Gelderland, Netherlands
Study Evaluating the Influence of LV5FU2 Bevacizumab Plus Anakinra Association on Metastatic Colorectal Cancer
- First Posted Date
- 2014-03-18
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- Centre Georges Francois Leclerc
- Target Recruit Count
- 32
- Registration Number
- NCT02090101
- Locations
- 🇫🇷
Centre Georges François Leclerc, Dijon, Burgundy, France
A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy
- Conditions
- Interventions
- First Posted Date
- 2013-12-27
- Last Posted Date
- 2017-01-31
- Lead Sponsor
- Baylor Research Institute
- Target Recruit Count
- 13
- Registration Number
- NCT02021422
- Locations
- 🇺🇸
Baylor Sammons Cancer Center, Dallas, Texas, United States
Role of Interleukin-1 in Postprandial Fatigue - The Cheesecake Study
- First Posted Date
- 2013-03-13
- Last Posted Date
- 2014-12-17
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 20
- Registration Number
- NCT01810549
- Locations
- 🇨🇭
University Hospital Basel, Basel, Switzerland
Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis
- Conditions
- Interventions
- First Posted Date
- 2013-03-12
- Last Posted Date
- 2021-11-01
- Lead Sponsor
- Mack Mitchell
- Target Recruit Count
- 104
- Registration Number
- NCT01809132
- Locations
- 🇺🇸
University of Louisville, Louisville, Kentucky, United States
🇺🇸University of Texas Southwestern Medical Center, Dallas, Texas, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Anakinra for Inflammatory Pustular Skin Diseases
- Conditions
- Interventions
- First Posted Date
- 2013-02-18
- Last Posted Date
- 2021-04-30
- Target Recruit Count
- 18
- Registration Number
- NCT01794117
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.