Pentoxifylline
- Generic Name
- Pentoxifylline
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C13H18N4O3
- CAS Number
- 6493-05-6
- Unique Ingredient Identifier
- SD6QCT3TSU
- Background
Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties. Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated...
- Indication
Pentoxifylline is indicated for the treatment of intermittent claudication in patients with chronic occlusive arterial disease. Pentoxifylline may improve limb function and reduce symptoms but cannot replace other therapies such as surgical bypass or removal of vascular obstructions.
- Associated Conditions
- Intermittent Claudication, Venous Leg Ulcer (VLU), Severe alcoholic liver disease
- Associated Therapies
- -
Pneumonitis Prevention Protocol Using Pentoxifylline and Α-tocopherol in Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation
- Conditions
- Interventions
- First Posted Date
- 2024-10-09
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 150
- Registration Number
- NCT06634056
- Locations
- 🇨🇦
University Health Network - Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Pentoxifylline Role Against Chemotherapy-induced Neuropathy
- Conditions
- Interventions
- First Posted Date
- 2024-08-20
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- Beni-Suef University
- Target Recruit Count
- 72
- Registration Number
- NCT06562998
- Locations
- 🇪🇬
University Hospital, Banī Suwayf, Beni-Suef, Egypt
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
- Conditions
- Interventions
- First Posted Date
- 2024-07-10
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 295
- Registration Number
- NCT06494111
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis
- Conditions
- Interventions
- First Posted Date
- 2024-05-20
- Last Posted Date
- 2024-05-20
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 75
- Registration Number
- NCT06422000
- Locations
- 🇪🇬
Tanta University, Tanta, El Gharbia, Egypt
Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-04-03
- Lead Sponsor
- The First Hospital of Hebei Medical University
- Target Recruit Count
- 200
- Registration Number
- NCT06344390
- Locations
- 🇨🇳
BHan, Shijiazhuang, China
Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2024-03-27
- Last Posted Date
- 2024-07-26
- Lead Sponsor
- Ziauddin University
- Target Recruit Count
- 30
- Registration Number
- NCT06332612
- Locations
- 🇵🇰
Ziauddin University, Karachi, Sindh, Pakistan
Efficacy of Intralesional Injection of Pentoxifylline, Platelet-Rich Plasma, and Combined Pentoxifylline With Platelet-Rich Plasma in Patients With Atrophic Acne Scars
- Conditions
- Interventions
- First Posted Date
- 2024-03-20
- Last Posted Date
- 2024-03-20
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 75
- Registration Number
- NCT06319768
- Locations
- 🇪🇬
Sohag university Hospital, Sohag, Egypt
Clinical Study Evaluating Efficacy, Safety and Molecular Mechanism of Both N-acetylcysteine and Pentoxifylline Supplementation in Patients With Hepatic and Post Hepatic Jaundice
- Conditions
- Interventions
- First Posted Date
- 2024-02-01
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 66
- Registration Number
- NCT06236165
- Locations
- 🇪🇬
Faculty of Pharmacy, Tanta University, Tanta, Egypt
Effect of Pentoxifylline on Preventing Chemotherapy-induced Mucositis in Patients With Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2024-01-02
- Last Posted Date
- 2024-03-15
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 80
- Registration Number
- NCT06186700
- Locations
- 🇪🇬
Oncology Center of Mansoura University, Mansoura, Egypt
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2023-11-02
- Last Posted Date
- 2023-11-02
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 44
- Registration Number
- NCT06115174
Drug Development Updates
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