DeepMed Research

Ketoprofen

Generic Name: Ketoprofen

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₄O_₃

CAS Number: 22071-15-4

Unique Ingredient Identifier: 90Y4QC304K

Background: Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Indication: For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.

Associated Conditions: Ankylosing Spondylitis (AS), Migraine, Mild pain, Osteoarthritis (OA), Post Partum Pain, Postoperative pain, Primary Dysmenorrhoea, Rheumatoid Arthritis, Moderate Pain

Clinical Trials

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Phase 2

Not yet recruiting

Conditions: Fibrosis Syndrome
Lymphedema
Head &Amp; Neck Cancer
Fibrosis

Interventions: Drug: Pravastatin (drug)
Drug: Pirfenidoneone
Drug: Pentoxifylline
Drug: ketoprofen
Other: Standard of Care (SOC)
Drug: tocopherol

First Posted Date: 2025-04-06

Last Posted Date: 2025-04-06

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 250

Registration Number: NCT06912763

Locations: 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States

Non-steroidal Anti-inflammatory in Cardiac Surgery

Not Applicable

Recruiting

Conditions: Non-steroidal Anti-inflammatory Drugs
Cardiac Surgery
Multimodal Pain Management
Pain Intensity
Acute Postoperative Pain

Interventions: Drug: pain management
Drug: PLacebo
Drug: ketoprofen

First Posted Date: 2024-04-24

Last Posted Date: 2024-04-24

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 238

Registration Number: NCT06381063

Locations: 🇫🇷
CHU Amiens Picardie, Amiens, France

PET Imaging of Cyclooxygenase in Multiple Sclerosis

Phase 2

Terminated

Conditions: Multiple Sclerosis

Interventions: Drug: 11C-MC1
Drug: 11C-PS13
Drug: Ketoprofen
Drug: Celecoxib

First Posted Date: 2021-09-30

Last Posted Date: 2024-06-27

Lead Sponsor: National Institute of Mental Health (NIMH)

Target Recruit Count: 7

Registration Number: NCT05062083

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Healthy Males

Phase 1

Completed

Conditions: No Condition

Interventions: Drug: Ketoprofen Lysine Salt combined with Gabapentin
Drug: Ketoprofen Lysine Salt
Other: Placebo
Drug: Gabapentin

First Posted Date: 2021-03-17

Last Posted Date: 2024-12-27

Lead Sponsor: Dompé Farmaceutici S.p.A

Target Recruit Count: 141

Registration Number: NCT04802967

Locations: 🇬🇧
MAC Clinical Research Early Phase Unit, Manchester, United Kingdom

Efficacy of CLORazepate for the Treatment of MIGraine Attack in the Emergency Room

Phase 3

Terminated

Conditions: Migraine
Migraine Without Aura
Migraine with Aura
Headache

Interventions: Drug: Clorazepate Dipotassium
Drug: Placebo
Drug: Ketoprofen
Drug: Metoclopramide

First Posted Date: 2021-01-27

Last Posted Date: 2024-10-26

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 323

Registration Number: NCT04726592

Locations: 🇫🇷
Hôpital Lariboisière, Paris, Ile-de-France, France

Bioequivalence of Ketoprofen Oral Gel vs Ketoprofen Lysine Salt as Granules for Oral Solution

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Ketoprofen Oral Product
Drug: Ketoprofen Lysine

First Posted Date: 2020-12-21

Last Posted Date: 2020-12-21

Lead Sponsor: Aziende Chimiche Riunite Angelini Francesco S.p.A

Target Recruit Count: 36

Registration Number: NCT04678076

Locations: 🇨🇭
CROSS Research S.A., Phase I Unit,, Arzo, Switzerland

Ketoprofen With or Without Vaginal Isonicotinic Acid Hydrazide Prior to Hysterosalpingography

Not Applicable

Completed

Conditions: Infertility, Female

Interventions: Drug: Ketoprofen + INH
Drug: Ketoprofen + placebo

First Posted Date: 2020-08-05

Last Posted Date: 2022-01-19

Lead Sponsor: Aswan University Hospital

Target Recruit Count: 200

Registration Number: NCT04500470

Locations: 🇪🇬
Aswan University Hospital, Aswan, Egypt

A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac

Phase 3

Completed

Conditions: Osteoarthritis

Interventions: Drug: Diclofenac Topical
Drug: Ketoprofen topical

First Posted Date: 2020-06-09

Last Posted Date: 2021-01-20

Lead Sponsor: Handok Inc.

Target Recruit Count: 236

Registration Number: NCT04421911

Locations: 🇷🇺
City Clinical Hospital #1 n.a. Pirogova, Moscow, Russian Federation
🇷🇺
Clinical Emergency Hospital n.a. N.V.Soloviev, Yaroslavl, Russian Federation
🇷🇺
Maksimum Zdorovya, Kemerovo, Russian Federation

and more 6 locations

Lymphedema Treatment Registry

Not yet recruiting

Conditions: Breast Cancer Lymphedema

Interventions: Drug: Ketoprofen

First Posted Date: 2020-02-17

Last Posted Date: 2023-09-07

Lead Sponsor: Ege University

Target Recruit Count: 60

Registration Number: NCT04272372

Sphenopalatine Blockade Versus Clinical Treatment

Not Applicable

Conditions: Headache, Post-Dural Puncture

Interventions: Drug: Dypirone
Drug: Ketoprofen
Procedure: Sphenopalatine block
Drug: Gabapentin
Drug: Dexamethasone
Drug: Theophylline
Dietary Supplement: Espresso coffee

First Posted Date: 2019-11-04

Last Posted Date: 2019-11-04

Lead Sponsor: University of Sao Paulo General Hospital

Target Recruit Count: 45

Registration Number: NCT04148846

Locations: 🇧🇷
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2025. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy