MedPath

Levocetirizine

Generic Name
Levocetirizine
Brand Names
Xyzal
Drug Type
Small Molecule
Chemical Formula
C21H25ClN2O3
CAS Number
130018-77-8
Unique Ingredient Identifier
6U5EA9RT2O
Background

Levocetirizine is a selective histamine H antagonist used to treat a variety of allergic symptoms. It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H receptor than cetirizine.

Levocetirizine was granted FDA approval in 1995.

Indication

Levocetirizine is indicated to treat symptoms of perennial allergic rhinitis and uncomplicated skin manifestations of chronic idiopathic urticaria. It is also used over the counter for a variety of mild allergy symptoms.

Associated Conditions
Allergic Rhinitis (AR), Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis
Associated Therapies
-

Clinical Study to Evaluate the Possible Efficacy and Safety of Levocetirizine in Patients With Diabetic Kidney Disease

Phase 2
Recruiting
Conditions
Diabetic Nephropathies
Interventions
First Posted Date
2022-12-06
Last Posted Date
2024-02-20
Lead Sponsor
Mostafa Bahaa
Target Recruit Count
60
Registration Number
NCT05638880
Locations
🇪🇬

Mansoura University, Mansoura, Egypt

A Phase I Study of LY3471851 in Healthy Participants

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: LY3471851
Drug: Placebo
Drug: Levocetirizine
First Posted Date
2022-10-04
Last Posted Date
2023-11-18
Lead Sponsor
Nektar Therapeutics
Target Recruit Count
41
Registration Number
NCT05565729
Locations
🇺🇸

Covance Dallas, Dallas, Texas, United States

A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma (HAS3)

Phase 3
Recruiting
Conditions
Allergic Asthma
Interventions
First Posted Date
2021-01-07
Last Posted Date
2024-04-26
Lead Sponsor
Bridgette Jones
Target Recruit Count
300
Registration Number
NCT04699604
Locations
🇺🇸

Children's Mercy Hospital, Kansas City, Missouri, United States

COrticosteroids in acUte uRticAria in emerGency dEpartment

Phase 3
Recruiting
Conditions
Urticaria
Angiœdema
Interventions
First Posted Date
2018-06-04
Last Posted Date
2024-05-14
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
240
Registration Number
NCT03545464
Locations
🇫🇷

Hospital Louis MOURIER, Colombes, Ile De France, France

Anti-inflammatory H1 Antihistamines Allergic Rhinitis

Phase 4
Completed
Conditions
Allergic Rhinitis
Interventions
First Posted Date
2015-07-24
Last Posted Date
2015-07-24
Lead Sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Target Recruit Count
115
Registration Number
NCT02507635

Phase 1 Study of Levocetirizine

Phase 1
Completed
Conditions
Dermatitis
Interventions
First Posted Date
2015-05-18
Last Posted Date
2017-08-03
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
20
Registration Number
NCT02447393
Locations
🇯🇵

GSK Investigational Site, Kagoshima, Japan

Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer

Phase 2
Completed
Conditions
Colorectal Neoplasms
Interventions
First Posted Date
2012-11-06
Last Posted Date
2017-04-20
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
47
Registration Number
NCT01722162
Locations
🇺🇸

Washington University School of Medicine, St. Louis, Missouri, United States

Efficacy and Safety of Concomitant Montelukast Sodium and Levocetirizine Dihydrochloride in Perennial Allergic Rhinitis (PAR) Patients

Phase 3
Completed
Conditions
Perennial Allergic Rhinitis
Interventions
First Posted Date
2012-07-13
Last Posted Date
2013-04-08
Lead Sponsor
Hanmi Pharmaceutical Company Limited
Target Recruit Count
283
Registration Number
NCT01640535
Locations
🇰🇷

Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, Korea, Republic of

Pharmacokinetic Study of Levocetirizine Oral Solution

Phase 1
Completed
Conditions
Rhinitis, Allergic, Perennial and Seasonal
Interventions
First Posted Date
2012-06-19
Last Posted Date
2017-06-12
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
20
Registration Number
NCT01622283
Locations
🇯🇵

GSK Investigational Site, Kagoshima, Japan

Bioequivalence Study of Levocetirizine Dihydrochloride Tablets 5 mg Under Fed Condition

First Posted Date
2012-03-30
Last Posted Date
2012-12-03
Lead Sponsor
IPCA Laboratories Ltd.
Target Recruit Count
28
Registration Number
NCT01567501
Locations
🇮🇳

Accutest Research Lab (I) Pvt. Ltd., Ahmedabad, Gujarat, India

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