Progesterone

Generic Name
Progesterone
Brand Names
Bijuva, Crinone, Endometrin, Prochieve, Prometrium
Drug Type
Small Molecule
Chemical Formula
C21H30O2
CAS Number
57-83-0
Unique Ingredient Identifier
4G7DS2Q64Y
Background

Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prev...

Indication

Gelatinized capsules

The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea .

Vaginal gel
...

Associated Conditions
Abnormal Uterine Bleeding, Amenorrhea, Endometrial hyperplasia caused by conjugated estrogen, Moderate to Severe Vasomotor Symptoms, Pregnancy, Secondary Amenorrhea, Recurrent spontaneous preterm birth
Associated Therapies
Assisted Reproductive Technology therapy
Clinical Trials
Related News

Vaginal PROgesterone as Maintenance Treatment After an epISode of prEterm Labor (PROMISE Study)

Phase 4
Completed
Conditions
Threatened Premature Labor
Interventions
Drug: Progesterone
Drug: Placebo
First Posted Date
2008-03-31
Last Posted Date
2016-08-19
Lead Sponsor
Hospital Clinic of Barcelona
Target Recruit Count
265
Registration Number
NCT00646802
Locations
🇪🇸

Hospital Sant joan de Déu de Manresa, Manresa, Barcelona, Spain

🇪🇸

Institut Universitari Dexeus, Barcelona, Spain

🇪🇸

Hospital Virgen de la Macarena, Seville, Spain

and more 9 locations

PREGNANT Short Cervix Trial

First Posted Date
2008-02-14
Last Posted Date
2012-03-13
Lead Sponsor
Juniper Pharmaceuticals, Inc.
Target Recruit Count
465
Registration Number
NCT00615550
Locations
🇺🇸

Johns Hopkins Community Physicians, Baltimore, Maryland, United States

🇺🇸

University of Miami Leonard Miller School of Medicine Department of Obstetrics and Gynecology, Miami, Florida, United States

🇺🇸

Caritas St. Elizabeth's Medical Center, Boston, Massachusetts, United States

and more 46 locations

Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues

Phase 1
Completed
Conditions
Cocaine Dependence
Interventions
Drug: Placebo
Drug: Progesterone
First Posted Date
2008-01-03
Last Posted Date
2014-02-12
Lead Sponsor
Yale University
Target Recruit Count
60
Registration Number
NCT00585520
Locations
🇺🇸

Yale University School of Medicine: Research Program on Stress, Addiction, and Psychopathology, New Haven, Connecticut, United States

Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism

Not Applicable
Terminated
Conditions
Postmenopausal Syndrome
Interventions
Drug: Estrogen
Drug: Placebo
Drug: Progesterone
First Posted Date
2007-11-30
Last Posted Date
2018-10-16
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
22
Registration Number
NCT00565916
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Vaginal Progesterone to Prevent Preterm Delivery in Women With Preterm Labor

First Posted Date
2007-09-27
Last Posted Date
2012-06-06
Lead Sponsor
begoña Martinez de Tejada
Target Recruit Count
384
Registration Number
NCT00536003
Locations
🇨🇭

University Hospital Zürich, Zurich, Switzerland

🇨🇭

Universitäts-Frauenklinik Kantonespital Basel, Basel, Switzerland

🇨🇭

Kantonales Frauenspital Chur, Chur, Switzerland

and more 30 locations

Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women

Phase 4
Completed
Conditions
Healthy
Postmenopausal
First Posted Date
2007-09-17
Last Posted Date
2007-09-17
Lead Sponsor
Max-Planck-Institute of Psychiatry
Target Recruit Count
10
Registration Number
NCT00530582
Locations
🇩🇪

Max Planck Institute of Psychiatry, Munich, Bavaria, Germany

Endometrial Effects of Daily Progesterone s.c. 25 and 50 Mg Aqueous Formulation to Female Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
First Posted Date
2006-09-19
Last Posted Date
2006-09-20
Lead Sponsor
IBSA Institut Biochimique SA
Target Recruit Count
24
Registration Number
NCT00377923

Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?

Phase 2
Completed
Conditions
Preterm Delivery
Interventions
Drug: Placebo
Drug: Progesterone
First Posted Date
2006-05-25
Last Posted Date
2011-07-25
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
677
Registration Number
NCT00329914
Locations
🇩🇰

Glostrup Hospital, Glostrup, Denmark

🇩🇰

Holbaek Hospital, Holbaek, Denmark

🇩🇰

Hvidovre Hospital, Hvidovre, Denmark

and more 14 locations

Multi-Center, Randomized, Open-Label, Parallel Group Study of a Vaginal Micronized Progesterone Tablet (Endometrin®) Compared to Crinone 8% Vaginal Gel in Female Patients Undergoing In-Vitro Fertilization (IVF)

Phase 3
Completed
Conditions
Fertility
Interventions
Drug: Crinone
Drug: Endometrin
First Posted Date
2006-02-27
Last Posted Date
2011-05-19
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
1211
Registration Number
NCT00296478

Effect of Progesterone on Smoking Behavior in Male and Female Smokers

Phase 1
Completed
Conditions
Tobacco Use Disorder
Interventions
Drug: sugar pill
Drug: Progesterone
First Posted Date
2005-12-30
Last Posted Date
2020-04-02
Lead Sponsor
Yale University
Target Recruit Count
65
Registration Number
NCT00271206
Locations
🇺🇸

VA Connecticut Health Care System, New Haven, Connecticut, United States

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