Progesterone

Generic Name
Progesterone
Brand Names
Bijuva, Crinone, Endometrin, Prochieve, Prometrium
Drug Type
Small Molecule
Chemical Formula
C21H30O2
CAS Number
57-83-0
Unique Ingredient Identifier
4G7DS2Q64Y
Background

Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prev...

Indication

Gelatinized capsules

The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea .

Vaginal gel
...

Associated Conditions
Abnormal Uterine Bleeding, Amenorrhea, Endometrial hyperplasia caused by conjugated estrogen, Moderate to Severe Vasomotor Symptoms, Pregnancy, Secondary Amenorrhea, Recurrent spontaneous preterm birth
Associated Therapies
Assisted Reproductive Technology therapy
Clinical Trials
Related News

Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial

First Posted Date
2015-06-12
Last Posted Date
2015-06-12
Lead Sponsor
Hillel Yaffe Medical Center
Target Recruit Count
430
Registration Number
NCT02470676

Progesterone Supplementation for HIV-positive Pregnant Women on Anti-Retrovirals

Phase 2
Conditions
HIV-1 Infection
Interventions
Drug: Prometrium
First Posted Date
2015-03-26
Last Posted Date
2015-07-30
Lead Sponsor
Mount Sinai Hospital, Canada
Target Recruit Count
40
Registration Number
NCT02400021
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

🇨🇦

St. Michael's Hospital, Toronto, Ontario, Canada

🇨🇦

Maple Leaf Medical Clinic, Toronto, Ontario, Canada

and more 2 locations

Lactoferrin or Progesterone for Prevention of Preterm Delivery

First Posted Date
2015-02-26
Last Posted Date
2018-05-08
Lead Sponsor
University of Padova
Target Recruit Count
1030
Registration Number
NCT02372942
Locations
🇮🇹

University of Padua, Padua, Italy

Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix

Phase 4
Completed
Conditions
Premature Labour
Interventions
Drug: Progesterone
First Posted Date
2015-01-14
Last Posted Date
2015-01-15
Lead Sponsor
Mohamed Sayed Abdelhafez
Target Recruit Count
182
Registration Number
NCT02338830
Locations
🇪🇬

Obstetrics and Gynecology Department in Mansoura University Hospital, Mansoura, Dakahlia, Egypt

🇪🇬

Private practice settings, Mansoura, Dakahlia, Egypt

Comparing Double Dose of Vaginal Progesterone to no Treatment for Prevention of Preterm Birth in Twins and Short Cervix

Not Applicable
Terminated
Conditions
Premature Birth
Interventions
Drug: Micronized progesterone
First Posted Date
2014-12-31
Last Posted Date
2017-08-21
Lead Sponsor
HaEmek Medical Center, Israel
Target Recruit Count
15
Registration Number
NCT02329535
Locations
🇮🇱

Haemek Medical Center, Afula, Israel

🇮🇱

The Nazareth hospital, Nazareth, Israel

Perimenopausal Effects of Estradiol on Reward Responsiveness

Phase 4
Completed
Conditions
Perimenopausal Depression
Interventions
Drug: Estradiol
Drug: Progesterone
First Posted Date
2014-10-02
Last Posted Date
2019-11-12
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
64
Registration Number
NCT02255175
Locations
🇺🇸

University of North Carolina, Chapel Hill, North Carolina, United States

Progesterone Effect on Individuals Diagnoses With AD and PTSD.

First Posted Date
2014-07-10
Last Posted Date
2023-04-26
Lead Sponsor
Yale University
Target Recruit Count
13
Registration Number
NCT02187224
Locations
🇺🇸

VA Connecticut Healtcase System, West Haven, Connecticut, United States

Progesterone for the Prevention of Miscarriage and Preterm Birth in Women With First Trimester Bleeding: PREEMPT Trial

Phase 2
Completed
Conditions
Preterm Birth
Miscarriage
Interventions
Drug: Placebo
Drug: Progesterone
First Posted Date
2014-05-23
Last Posted Date
2021-08-23
Lead Sponsor
Sir Mortimer B. Davis - Jewish General Hospital
Target Recruit Count
850
Registration Number
NCT02145767
Locations
🇨🇦

St. Mary's Hospital, Montreal, Quebec, Canada

🇨🇦

CHU Sainte-Justine, Montreal, Quebec, Canada

🇨🇦

MUHC Royal Victoria Hospital, Montreal, Quebec, Canada

and more 4 locations

Randomized Trial of Maternal Progesterone Therapy

First Posted Date
2014-05-08
Last Posted Date
2023-08-09
Lead Sponsor
Children's Hospital of Philadelphia
Target Recruit Count
102
Registration Number
NCT02133573
Locations
🇺🇸

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

The Effect of Different Types of Progestin on Sleeping of Menopausal Women

First Posted Date
2014-03-13
Last Posted Date
2017-05-31
Lead Sponsor
Chiang Mai University
Target Recruit Count
100
Registration Number
NCT02086032
Locations
🇹🇭

Obstetrics and Gynecology department, Faculty of Medicine, Chiang Mai University, Muang, Chiang Mai, Thailand

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