MedPath

Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea
Associated Therapies
-

Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome

Phase 1
Completed
Conditions
Respiratory Distress Syndrome
Premature Infants
Interventions
First Posted Date
2020-05-28
Last Posted Date
2020-06-09
Lead Sponsor
Poznan University of Medical Sciences
Target Recruit Count
23
Registration Number
NCT04404816
Locations
🇵🇱

Gynecological and obstetric teaching hospital, Departament of Neonatology, Polna street 33, Poznań, Great Poland, Poland

Nitrous Oxide for PTSD

Phase 2
Terminated
Conditions
PTSD
Interventions
First Posted Date
2020-05-07
Last Posted Date
2023-03-03
Lead Sponsor
VA Office of Research and Development
Target Recruit Count
1
Registration Number
NCT04378426
Locations
🇺🇸

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California, United States

O2 Versus CPAP Treatment Of Patients Undergoing SIPE Therapy (OCTOPUS)

Not Applicable
Recruiting
Conditions
Pulmonary Edema
Swimming Induced Pulmonary Edema (SIPE)
Lung Diseases
Interventions
Combination Product: Oxygen + continuous positive airway pressure (CPAP)
Drug: Oxygen
First Posted Date
2020-03-13
Last Posted Date
2024-01-10
Lead Sponsor
Dalarna County Council, Sweden
Target Recruit Count
90
Registration Number
NCT04307615
Locations
🇸🇪

Center of Clinical Research Dalarna, Falun, Sweden

Ozone Therapy in Chemotherapy-induced Peripheral Neuropathy: RCT (O3NPIQ)

Phase 2
Recruiting
Conditions
Pain, Neuropathic
Chemotherapy-induced Peripheral Neuropathy
Pain Syndrome
Interventions
First Posted Date
2020-03-09
Last Posted Date
2024-03-04
Lead Sponsor
Bernardino Clavo, MD, PhD
Target Recruit Count
42
Registration Number
NCT04299893
Locations
🇪🇸

Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas De Gran Canaria, Las Palmas, Spain

🇪🇸

Complejo Hospitalario Materno Insular, Las Palmas De Gran Canaria, Las Palmas, Spain

Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

Phase 3
Conditions
Anesthesia
Perioperative Complication
Pneumonia
Wound Infection
Postoperative Complications
Laparotomy
Surgical Wound Infection
Pathologic Processes
Chlorhexidine
Infection
Interventions
First Posted Date
2020-02-05
Last Posted Date
2020-11-25
Lead Sponsor
University of Birmingham
Target Recruit Count
12942
Registration Number
NCT04256798
Locations
🇿🇦

Groote Schuur Hospital, Cape Town, South Africa

NO During CPB in Neonates to Reduce Risk of AKI

Phase 3
Recruiting
Conditions
AKI
CHD - Congenital Heart Disease
Surgery
Interventions
First Posted Date
2020-01-03
Last Posted Date
2024-03-22
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
40
Registration Number
NCT04216927
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia

Phase 2
Completed
Conditions
Oxygen Deficiency
Pulmonary Arterial Hypertension
CTEPH
Interventions
First Posted Date
2019-12-23
Last Posted Date
2024-06-20
Lead Sponsor
Heidelberg University
Target Recruit Count
20
Registration Number
NCT04207593
Locations
🇩🇪

Centre for pulmonary hypertension of the Thoraxclinic at the University Hospital Heidelberg, Heidelberg, Germany

Conservative Versus Conventional Oxygen Administration in Critically Ill Patients

Phase 4
Conditions
Critical Illness
Hyperoxemia
Hyperoxia
Respiration, Artificial
Interventions
First Posted Date
2019-12-13
Last Posted Date
2021-05-04
Lead Sponsor
University of Modena and Reggio Emilia
Target Recruit Count
1000
Registration Number
NCT04198077
Locations
🇮🇹

Girardis Massimo, Modena, Italy

Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study

Phase 4
Conditions
Hyperoxia
Cardiac Surgery
Cardiopulmonary Bypass
Acute Lung Injury
Oxygen Toxicity
Interventions
First Posted Date
2019-10-21
Last Posted Date
2019-10-28
Lead Sponsor
Aalborg University Hospital
Target Recruit Count
50
Registration Number
NCT04133740
Locations
🇩🇰

Dept. of Intensive Care, Aalborg University Hospital, Aalborg, Denmark

Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome

Phase 3
Completed
Conditions
Complex Regional Pain Syndrome
Interventions
First Posted Date
2019-03-18
Last Posted Date
2024-02-09
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
44
Registration Number
NCT03879538
Locations
🇺🇸

Cleveland Clinic Pain Management, Cleveland, Ohio, United States

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