MedPath

Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea

Substudy of Protocol 2019-002498-80 - NCT04223050: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)

Phase 4
Terminated
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
First Posted Date
2021-09-22
Last Posted Date
2025-03-11
Lead Sponsor
Mikkel Brabrand
Target Recruit Count
23
Registration Number
NCT05052125
Locations
🇩🇰

Hospital of Southern Denmark, Esbjerg, Esbjerg, Denmark

🇩🇰

Kolding Hospital, Sygehus Lillebælt, Kolding, Denmark

Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock

Phase 3
Completed
Conditions
Extracorporeal Membrane Oxygenation
Cardiogenic Shock
Interventions
First Posted Date
2021-08-04
Last Posted Date
2024-12-30
Lead Sponsor
Centre Hospitalier Universitaire de Besancon
Target Recruit Count
60
Registration Number
NCT04990349
Locations
🇫🇷

CHU de Besançon, Besancon, France

Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial

Phase 4
Completed
Conditions
Treatment Resistant Depression
Major Depressive Disorder
Interventions
Drug: Nitrous Oxide 99 %
First Posted Date
2021-07-12
Last Posted Date
2024-05-08
Lead Sponsor
Unity Health Toronto
Target Recruit Count
40
Registration Number
NCT04957368
Locations
🇨🇦

St. Michael's Hospital, Toronto, Ontario, Canada

Impact of Oxygen Therapy on Fatigue in Patients With Hypermobile-type Ehlers-Danlos Syndrome

Phase 4
Conditions
Ehlers-Danlos Syndrome
Interventions
Drug: Placebo
First Posted Date
2021-05-18
Last Posted Date
2022-03-31
Lead Sponsor
Hospital St. Joseph, Marseille, France
Target Recruit Count
82
Registration Number
NCT04890431
Locations
🇫🇷

Hopital Raymond Poincaré, Garches, France

🇫🇷

Hopital Saint Joseph, Marseille, France

🇫🇷

Clinique de la Mitterie, Lille, France

Repeated HBO Therapy in Myeloma Patients Undergoing High-Dose Therapy and Auto-HCT

Early Phase 1
Active, not recruiting
Conditions
Myeloma
Interventions
First Posted Date
2021-04-28
Last Posted Date
2025-04-03
Lead Sponsor
University of Rochester
Target Recruit Count
15
Registration Number
NCT04862676
Locations
🇺🇸

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States

Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome

Phase 2
Completed
Conditions
COVID-19
Post-Acute COVID-19 Syndrome
Post COVID-19 Condition
Post COVID Condition
Post-COVID Syndrome
Post COVID-19 Condition, Unspecified
Interventions
Procedure: Sham treatment
First Posted Date
2021-04-13
Last Posted Date
2024-08-22
Lead Sponsor
Karolinska University Hospital
Target Recruit Count
80
Registration Number
NCT04842448
Locations
🇸🇪

Karolinska University Hospital, Stockholm, Sweden

Comparative Study Between Liberal and Conservative Oxygen Therapy in Mechanically Ventilated Intensive Care Patients

Not Applicable
Completed
Conditions
Oxygen Therapy
Interventions
First Posted Date
2021-04-01
Last Posted Date
2024-04-30
Lead Sponsor
Aswan University Hospital
Target Recruit Count
106
Registration Number
NCT04824703
Locations
🇪🇬

Aswan university hospital, Aswan, Egypt

Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

Not Applicable
Recruiting
Conditions
Coronary Artery Disease
Anesthesia
Interventions
First Posted Date
2021-03-22
Last Posted Date
2024-12-13
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
110
Registration Number
NCT04808401
Locations
🇨🇭

Bern University Hospital, Inselspital, Bern, Switzerland

Hyperbaric Oxygen and Outcome After Below Knee Amputations

Phase 1
Terminated
Conditions
Amputation; Postoperative, Sequelae
Interventions
First Posted Date
2021-01-22
Last Posted Date
2024-08-12
Lead Sponsor
Duke University
Target Recruit Count
5
Registration Number
NCT04717557
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

To Develop Methods for the Rehabilitation of Chronic Gastroduodenal Pathology in Children.

Not Applicable
Active, not recruiting
Conditions
Gastritis Chronic
Peptic Ulcer
Gastroduodenitis
Duodenal Ulcer
Interventions
First Posted Date
2021-01-11
Last Posted Date
2025-05-21
Lead Sponsor
Tashkent State Medical University (Tashkent Pediatric Medical Institute), Uzbekistan
Target Recruit Count
320
Registration Number
NCT04702542
Locations
🇺🇿

Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

© Copyright 2025. All Rights Reserved by MedPath