Gentamicin

Generic Name: Gentamicin

Brand Names: Gentak, Pred-G, Valisone-G

Drug Type: Small Molecule

Chemical Formula: C_₆₀H_₁₂₃N_₁₅O_₂₁

CAS Number: 1403-66-3

Unique Ingredient Identifier: T6Z9V48IKG

Background: Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment ...

Indication: 1.本品适用于敏感铜绿假单胞菌、变形杆菌（吲哚阳性和阴性）属、大肠埃希菌、克雷伯菌属、肠杆菌属、沙雷菌属、柠檬酸杆菌属以及葡萄球菌属（不包括耐甲氧西林菌株）所致的严重感染；临床上本品常与β内酰胺类或其他抗菌药物联合应用。本品与青霉素G（或氨苄西林）联合应用治疗肠球菌感染；

2.本品用于铜绿假单胞菌或葡萄球菌属所致的严重中枢神经系统感染（如脑膜炎、脑室炎）时，可同时用本品鞘内注射作为辅助治疗；

3.本品不适用于单纯性尿路感染初治，除非病原菌对其他毒性较低的抗菌药物不敏感，本品对链球菌属中多数菌种（尤其D组）、肺炎链球菌和厌氧菌（如拟杆菌属或梭状芽孢杆菌属）无效；

4.本品口服可用于肠道感染或结肠手术前准备，也可用本品肌注合并克林霉素或甲硝唑以减少结肠手术后感染率。
...

Associated Conditions: Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Bacterial Infections, Bacterial Keratitis, Bacterial Peritonitis, Bacterial dacryocystitis, Blepharoconjunctivitis, Central Nervous System Infections, Corneal infection, Dermatitis infected, Ecthyma, Eczematous dermatitis infected, Folliculitis, Furunculosis, Gram-negative enteric bacilli neonatal sepsis, Impetigo contagious, Inflammation, Keratoconjunctivitis, Meibomianitis, Meningitis, Bacterial, Ocular Inflammation, Pustular Psoriasis (PP), Pustular acne, Pyoderma Gangrenosum, Seborrheic Dermatitis, Septicemia gram-negative, Skin Infections, Skin and Subcutaneous Tissue Bacterial Infections, Sycosis barbae, Bacterial blepharitis, Bacterial corneal ulcers, Bacterial skin infections, Complicated Respiratory tract infection bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Corticosteroid-responsive dermatoses, Ocular bacterial infections, Severe Endocarditis enterococcal, Severe Infection Pseudomonas aeruginosa, Severe Staphylococcal infection

Associated Therapies: -

Clinical Trials

Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

Phase 3

Recruiting

Conditions: Penile Prosthesis; Complications, Infection or Inflammation
Erectile Dysfunction

Interventions: Drug: Chlorhexidine
Drug: Gentamicin
Drug: Rifampin

First Posted Date: 2024-07-05

Last Posted Date: 2024-08-26

Lead Sponsor: Rush University Medical Center

Target Recruit Count: 100

Registration Number: NCT06489431

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
🇺🇸
Uropartners Surgery Center, Des Plaines, Illinois, United States

ORal Antibiotics In Acute Mesenteric Ischemia

Phase 3

Not yet recruiting

Conditions: Acute Mesenteric Ischemia

Interventions: Drug: Placebo
Drug: Gentamicin
Drug: Metronidazole

First Posted Date: 2024-04-26

Last Posted Date: 2024-04-26

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 196

Registration Number: NCT06387147

Locations: 🇫🇷
Gastroentérologie-Hépatologie Beaujon, Clichy, France
🇫🇷
Réanimation - Beaujon, Clichy, France
🇫🇷
Chirurgie vasculaire, Paris, France

and more 1 locations

Intravesical Gentamicin to Prevent Recurrent UTI

Phase 4

Not yet recruiting

Conditions: Recurrent Uti

Interventions: Drug: Nitrofurantoin
Drug: Gentamicin

First Posted Date: 2024-03-27

Last Posted Date: 2024-03-28

Lead Sponsor: Women and Infants Hospital of Rhode Island

Target Recruit Count: 30

Registration Number: NCT06332781

Gentamicin Bladder Instillation on CAUTI

Phase 4

Recruiting

Conditions: Catheter Infection

Interventions: Drug: Gentamicin

First Posted Date: 2024-03-26

Last Posted Date: 2024-03-26

Lead Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Target Recruit Count: 400

Registration Number: NCT06332040

Locations: 🇺🇸
St. Jpseph's Hospital and Medical Center, Phoenix, Arizona, United States

The Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications.

Not Applicable

Recruiting

Conditions: Post-TURP Infectious Complications

Interventions: Procedure: Transurethral resection of the prostate (TURP)
Drug: normal saline
Drug: Gentamicin

First Posted Date: 2023-12-13

Last Posted Date: 2023-12-13

Lead Sponsor: Tanta University

Target Recruit Count: 220

Registration Number: NCT06168708

Locations: 🇪🇬
Urolgy Departement, Faculty of Medicine, Tanta University, Tanta, Outside U.S./Canada, Egypt

Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis

Phase 2

Not yet recruiting

Conditions: Urinary Tract Infections
Sepsis

Interventions: Drug: Gentamicin
Other: Placebo

First Posted Date: 2023-08-23

Last Posted Date: 2024-07-23

Lead Sponsor: Yale University

Target Recruit Count: 412

Registration Number: NCT06007352

Locations: 🇺🇸
Yale New Haven Health, New Haven, Connecticut, United States

NICU Antibiotics and Outcomes (NANO) Follow-up Study

Phase 3

Not yet recruiting

Conditions: Antibiotics
Neurodevelopment
Premature Birth

Interventions: Drug: Placebo
Drug: Ampicillin
Drug: Gentamicin

First Posted Date: 2023-08-04

Last Posted Date: 2023-08-04

Lead Sponsor: Sharp HealthCare

Target Recruit Count: 802

Registration Number: NCT05977400

Locations: 🇺🇸
Westchester Medical Center, Valhalla, New York, United States
🇺🇸
Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
🇨🇦
Sinai Health System, Toronto, Canada

and more 12 locations

Intramedullary Calcium Sulfate Antibiotic Depot

Phase 3

Recruiting

Conditions: Osteomyelitis Tibia
Open tíbia Fracture
Tibial Fractures

Interventions: Drug: Vancomycin Hydrochloride
Other: Standard Intramedullary Nail
Drug: Gentamicin

First Posted Date: 2023-03-13

Last Posted Date: 2024-12-02

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 497

Registration Number: NCT05766670

Locations: 🇺🇸
Atrium Health Cabarrus, Concord, North Carolina, United States
🇺🇸
Pennsylvania State University, Hershey, Pennsylvania, United States
🇺🇸
University of Kentucky, Lexington, Kentucky, United States

and more 7 locations