Ticagrelor

Generic Name
Ticagrelor
Brand Names
Brilinta, Brilique
Drug Type
Small Molecule
Chemical Formula
C23H28F2N6O4S
CAS Number
274693-27-5
Unique Ingredient Identifier
GLH0314RVC
Background

Ticagrelor, or AZD6140, was first described in the literature in 2003. Ticagrelor is an ADP derivative developed for its P2Y receptor antagonism. Unlike clopidogrel, ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,.

Ticagrelor was granted EMA approval on 3 December 2010.
...

Indication

Ticagrelor is indicated to reduce the risk of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction. Ticagrelor is also indicated to reduce the risk of a first myocardial infarction or stroke in high risk patients with coronary artery disease.

Associated Conditions
Cardiovascular Mortality, Myocardial Infarction, Stroke, Thrombosis (Stent Thrombosis)
Associated Therapies
-

Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

First Posted Date
2016-08-15
Last Posted Date
2020-05-06
Lead Sponsor
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Target Recruit Count
1506
Registration Number
NCT02866175
Locations
🇺🇦

Kharkiv City Clinical Hospital #8, Kharkiv, Ukraine

🇬🇧

Altnagelvin Area Hospital, Londonderry, United Kingdom

🇬🇧

Golden Jubilee Hospital, Clydebank, United Kingdom

and more 197 locations

Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction

First Posted Date
2016-06-22
Last Posted Date
2017-08-11
Lead Sponsor
Faculty Hospital Kralovske Vinohrady
Target Recruit Count
1226
Registration Number
NCT02808767
Locations
🇨🇿

Faculty Hospital Kralovske Vinohrady, Prague, Czechia

Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction

First Posted Date
2016-06-14
Last Posted Date
2016-06-14
Lead Sponsor
Chinese PLA General Hospital
Target Recruit Count
240
Registration Number
NCT02798874
Locations
🇨🇳

Chinese People's Liberation Army General Hospital, Peking, Beijing, China

Ticagrelor Versus Clopidogrel in Myocardial Salvage in Patients With STEMI Undergoing Primary PCI

First Posted Date
2016-06-07
Last Posted Date
2016-06-07
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
200
Registration Number
NCT02792712
Locations
🇨🇳

Teipei Veterans General Hospital, Taipei, Taiwan

Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit

First Posted Date
2016-05-05
Last Posted Date
2016-05-05
Lead Sponsor
Chang Gung Memorial Hospital
Target Recruit Count
200
Registration Number
NCT02762864

Platelet Inhibition of Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients After Elective Percutaneous Coronary Intervention

First Posted Date
2016-04-22
Last Posted Date
2019-03-21
Lead Sponsor
Peking Union Medical College Hospital
Target Recruit Count
40
Registration Number
NCT02748330
Locations
🇨🇳

Peking Union Medical College Hospital, Beijing, Beijing, China

Clopidogrel Versus Ticagrelor in Type-2 Diabetes

First Posted Date
2016-04-19
Last Posted Date
2017-08-17
Lead Sponsor
Campus Bio-Medico University
Target Recruit Count
42
Registration Number
NCT02742987

The Effect of IV Cangrelor and Oral Ticagrelor Study

First Posted Date
2016-04-11
Last Posted Date
2018-10-31
Lead Sponsor
The Royal Wolverhampton Hospitals NHS Trust
Target Recruit Count
100
Registration Number
NCT02733341
Locations
🇬🇧

The Royal Wolverhampton NHS Trust, Wolverhampton, United Kingdom

High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-03-04
Last Posted Date
2016-03-04
Lead Sponsor
Wuhan Asia Heart Hospital
Target Recruit Count
477
Registration Number
NCT02699008
Locations
🇨🇳

Wuhan Asia Heart Hospital, Wuhan, Hubei, China

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

First Posted Date
2016-02-09
Last Posted Date
2022-06-28
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
210
Registration Number
NCT02677545
Locations
🇨🇭

Kantonsspital Aarau Klinik für Neurologie, Aarau, Switzerland

🇮🇹

Ospedale Civile di Mirano, Department of Cardiology, Mirano, Italy

🇧🇪

Ghent University Hospital - Dept thoracic and vascular surgery, Ghent, Belgium

and more 12 locations
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